Abasic sites and survival in resected patients with non-small cell lung cancer

Cancer Letters
Hua ZhaoJay D Hunt

Abstract

Apurinic/apyrimidinic (AP or abasic) sites are common DNA lesions that arise from spontaneous depurination or by base excision repair (BER) of modified bases. Accumulation of impaired AP sites could lead to increased genomic instability that in turn could lead to a more malignant phenotypic behavior of tumors. We, therefore, evaluated the effects of AP sites on survival in resected non-small cell lung cancer (NSCLC) patients. Resected tumor specimens from 99 patients with NSCLC who underwent surgical resection were collected. The enzyme-linked immunosorbent assay was applied to measure the levels of AP sites in tumor DNA. The median number of AP sites per 10(5) nucleotides was 12.4 for all the study subjects. Patients with low levels of AP site had significantly longer survival time compared with ones with medium or high levels of AP site (log-rank test: P=0.015). In Cox regression analysis, patients with medium or high levels of AP sites had over twofold increased hazard of death. In addition, we found a statistically significant correlation between levels of AP sites and age (rho=0.560, P<0.001). The results of this study demonstrated that levels of AP sites could predict survival in resected NSCLC patients. We postulate that...Continue Reading

References

Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W Zhou, P W Doetsch
Jan 10, 1997·The Journal of Biological Chemistry·P S Kingma, N Osheroff
Nov 5, 1997·The Journal of Biological Chemistry·D L Croteau, V A Bohr
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·B J GlassnerL D Samson
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H AtamnaB N Ames
Oct 4, 2002·Oncogene·Ana I RoblesCurtis C Harris
Oct 16, 2002·Oncogene·Michael J ThunEugenia E Calle
Dec 10, 2002·Experimental Gerontology·Tinna StevnsnerVilhelm A Bohr
Jul 29, 2003·Exercise and Sport Sciences Reviews·Holly Van RemmenA Richardson
Sep 4, 2003·Journal of the National Cancer Institute·Tamar Paz-ElizurZvi Livneh
Jul 27, 2004·Mechanisms of Ageing and Development·Zarir E Karanjawala, Michael R Lieber
Jul 29, 2004·DNA Repair·Ari Barzilai, Ken-Ichi Yamamoto
Aug 24, 2004·Oncogene·Xifeng WuDavid C Christiani
Oct 12, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R RosellC Balaña
Nov 4, 2004·International Journal of Cancer. Journal International Du Cancer·Daniel GackowskiRyszard Olinski
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael S BobolaJohn R Silber
Feb 23, 2005·Cancer Letters·Zsolt RadakIldiko Horvath
Apr 21, 2005·Journal of the National Cancer Institute·Rayjean J HungPaolo Boffetta
Apr 26, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M C SantosA Bugalho De Almeida

❮ Previous
Next ❯

Citations

Jan 12, 2010·Mutation Research·Olga A SedelnikovaWilliam M Bonner
Dec 14, 2007·American Journal of Physiology. Cell Physiology·Craig RicciStephen W Schaffer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.