Abatacept in psoriatic arthritis: Case report and short review

Journal of Pharmacology & Pharmacotherapeutics
Francesco UrsiniRosa Daniela Grembiale

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting about 6-10% of patients with cutaneous psoriasis. According to current knowledge, activated T-cells seem to play a pivotal role in the pathogenesis of both psoriasis and PsA. Abatacept is a novel biologic agent selectively designed to interfere with T-cells co-stimulation. Structurally, it is a soluble, fully human fusion protein consisting of the extracellular domain of CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) linked to a modified Fc portion of human IgG1. Abatacept is now approved as a first-line treatment for rheumatoid arthritis (RA), but preliminary data disclose a potential role of abatacept in the treatment of other autoimmune diseases. In this article, we report a case of successful treatment with abatacept of a psoriatic arthritis patients who developed adverse drug reactions (ADRs) to medication commonly used in PsA, including three different anti-TNF-α agents. In addition, we review the scientific evidences supporting a possible role of abatacept in treatment of patients with psoriasis and PsA and the paradox of abatacept-induced psoriasis.

Citations

Nov 10, 2014·Immunologic Research·Carlo SelmiCarlo A Sciré
Jul 9, 2016·Seminars in Arthritis and Rheumatism·Laura C CoatesCarle Paul
Jul 3, 2015·Therapeutic Advances in Chronic Disease·Eun Jin Kang, Arthur Kavanaugh
Jan 22, 2015·Arthritis Research & Therapy·Sabrina CeerazRandolph J Noelle
Apr 3, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Brian A Baldo
Aug 11, 2017·European Journal of Clinical Investigation·Francesco UrsiniSalvatore D'angelo
May 17, 2019·Journal of Psoriasis and Psoriatic Arthritis·Sara Jiayang LiJoseph F Merola

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.