ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis

PloS One
Sonam KumariNaseem A Gaur

Abstract

ATP-binding cassette (ABC) is one of the two major superfamilies of transporters present across the evolutionary scale. ABC superfamily members came to prominence due to their ability to extrude broad spectrum of substrates and to confer multi drug resistance (MDR). Overexpression of some ABC transporters in clinical isolates of Candida species was attributed to the development of MDR phenotypes. Among Candida species, Candida glabrata is an emerging drug resistant species in human fungal infections. A comprehensive analysis of such proteins in C. glabrata is required to untangle their role not only in MDR but also in other biological processes. Bioinformatic analysis of proteins encoded by genome of human pathogenic yeast C. glabrata identified 25 putative ABC protein coding genes. On the basis of phylogenetic analysis, domain organization and nomenclature adopted by the Human Genome Organization (HUGO) scheme, these proteins were categorized into six subfamilies such as Pleiotropic Drug Resistance (PDR)/ABCG, Multi Drug Resistance (MDR)/ABCB, Multi Drug Resistance associated Protein (MRP)/ABCC, Adrenoleukodystrophy protein (ALDp)/ABCD, RNase L Inhibitor (RLI)/ABCE and Elongation Factor 3 (EF3)/ABCF. Among these, only 18 ABC p...Continue Reading

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Citations

Aug 7, 2020·FEMS Yeast Research·Garima ShahiRajendra Prasad
Sep 29, 2019·Research in Microbiology·Alexis MorenoPierre Falson
Feb 3, 2021·Microbiological Research·Ján Víglaš, Petra Olejníková
Mar 7, 2021·Fungal Genetics and Biology : FG & B·Sonam KumariRajendra Prasad
May 7, 2021·Biochimica Et Biophysica Acta. Biomembranes·Poonam VishwakarmaAtanu Banerjee

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Software Mentioned

BLASTp
WoLF PSORT
Scan Prosite
Scan
Circos
MEGA6
ClustalW
LocTree3
HMMER
Topocons

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