ABCC2 haplotype is not associated with drug-resistant epilepsy

The Journal of Pharmacy and Pharmacology
Takayuki SeoKazuko Nakagawa

Abstract

Several studies have investigated the association between the ABCB1 polymorphism and drug-resistant epilepsy. However, the effect of ABCC2 polymorphisms on anti-epileptic drug (AED) responsiveness remains unknown. The ABCC2 polymorphisms have been genotyped in 279 Japanese epileptic patients treated with AEDs. The association between the AED responsiveness and the polymorphisms was estimated by a haplotype-based analysis. No genotype or haplotype was associated with drug-resistant epilepsy. On the other hand, the delGCGC haplotype at G-1774delG, C-24T, G1249A and C3972T was over represented among the epileptic patients with a complication of mental retardation in comparison with those without (32.4% vs 22.0%; P=0.009); and the G-1774delG allele was also associated with mental retardation (P=0.03). No association between the ABCC2 genotypes or haplotypes, and the responsiveness of AEDs was observed, although this finding was inconclusive because of the small sample size.

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Citations

Jun 18, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Ortrud K Steinlein
Jul 30, 2011·Pharmacogenetics and Genomics·Mike UferIngolf Cascorbi
May 20, 2009·Pharmacogenomics·Dalia Kasperaviciūte, Sanjay M Sisodiya
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Sep 1, 2008·Expert Review of Clinical Pharmacology·Sunao KanekoHiroto Iwasa
May 29, 2018·Expert Opinion on Drug Metabolism & Toxicology·Azzurra OrlandiPasquale Parisi

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