Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice

Journal of Neurochemistry
Yu ZengWandong Zhang

Abstract

Oxidative stress and neuroinflammation play important roles in Alzheimer's disease (AD). ABCG2 is a transporter protein expressed in the brain and involved in GSH transport. To study the roles of Abcg2 in oxidative stress and AD, we cross-bred Tg-SwDI and Abcg2-KO mice and generated Tg-SwDI/Abcg2-KO (double-tg) mice. Brain tissues from double-tg, Tg-SwDI, wild-type, and Abcg2-KO mice at various ages were analyzed. Aβ40 and Aβ42 were detected in Tg-SwDI and double-tg mice. Total brain GSH was decreased and levels of lipid/DNA oxidation were increased in 3-month double-tg compared to Tg-SwDI mice. Low brain GSH was still detected in 9-month double-tg mice. Increased HMOX-1 and MCP-5 expression was observed in 9-month double-tg mice but not in Tg-SwDI mice compared to WT and Abcg2-KO mice. Increased HMOX-1 and decreased ICAM-1 expression were observed in 12-month double-tg mice compared to Tg-SwDI mice. The levels of Nrf-2 expression and activity were decreased in 6-month double-tg mice. Behavioral tests show impaired cognitive/memory performance of 9-month double-tg compared to Tg-SwDI mice as well as WT and Abcg2-KO mice. These results suggest that Abcg2 deficiency increases oxidative stress and alters inflammatory response in t...Continue Reading

References

Oct 18, 2000·Free Radical Biology & Medicine·E Cadenas, K J Davies
May 30, 2001·Neurobiology of Aging·M N GordonG W Arendash
Jan 5, 2002·Neurobiology of Aging·P Grammas, R Ovase
Jul 12, 2002·Journal of Neural Transmission·K A Jellinger
Jan 22, 2003·Advanced Drug Delivery Reviews·Alfred H Schinkel, Johan W Jonker
Jun 27, 2003·Free Radical Biology & Medicine·Elena TamagnoOliviero Danni
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wandong ZhangDanica B Stanimirovic
Dec 21, 2004·Chemical Research in Toxicology·Debra Boyd-KimballD Allan Butterfield
Sep 9, 2005·The AAPS Journal·Qingcheng Mao, Jashvant D Unadkat
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hani Atamna, Kathleen Boyle
May 25, 2007·Journal of Alzheimer's Disease : JAD·Tadeusz Malinski
Jul 28, 2007·Journal of Alzheimer's Disease : JAD·Milan FialaGeorge Bernard
Jul 31, 2007·Current Opinion in Pharmacology·Molly M Gallogly, John J Mieyal
Dec 20, 2007·Journal of Neurochemistry·Claudie HooperSimon Lovestone
Mar 7, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Junichi EnokizonoYuichi Sugiyama
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Regina M Day, Yuichiro J Suzuki
Sep 11, 2008·Journal of Alzheimer's Disease : JAD·Geneviève LeubaBéat Michel Riederer
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huaqi XiongWandong Zhang
Sep 29, 2009·Experimental Neurology·Félix HernándezJesús Avila
Mar 25, 2010·The Journal of Biological Chemistry·Heather M BrechbuhlBrian J Day
May 13, 2010·Reviews in the Neurosciences·Shanshan Shen, Wandong Zhang
Jul 16, 2010·Journal of Neurochemistry·Shanshan ShenWandong Zhang
Mar 2, 2011·Physiology·Paul H AxelsenIan V J Murray

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Citations

May 2, 2014·Frontiers in Pharmacology·Deborah ChiabrandoEmanuela Tolosano
Dec 8, 2014·Archives of Medical Research·Patricia Campos-BedollaMária A Deli
Jul 23, 2016·Clinical Pharmacology and Therapeutics·H QosaA Kaddoumi
Oct 13, 2016·Frontiers in Aging Neuroscience·Farron L McInteeJorge Ghiso
Nov 25, 2017·Journal of Alzheimer's Disease : JAD·Cátia D PereiraSandra Rebelo
Apr 13, 2019·Current Topics in Medicinal Chemistry·Niraj Kumar JhaRituraj Niranjan
Oct 26, 2018·Frontiers in Neuroscience·Deborah ChiabrandoEmanuela Tolosano
May 31, 2019·BMC Veterinary Research·Xuedong DingJinjie Wu
Aug 19, 2020·Asian-Australasian Journal of Animal Sciences·Xuedong DingJinjie Wu
Apr 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Bei ZhangGang Li

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