PMID: 18713655Aug 21, 2008Paper

ABCs of Asthma

Clinical Cornerstone
David I Bernstein

Abstract

Asthma results from chronic airway inflammation involving a diversity of activated cells including mast cells, eosinophils, T-lymphocytes, neutrophils, macrophages, and epithelial cells. These cells release proinflammatory cytokine mediators that augment and regulate airway inflammation, leading to airway hyperresponsiveness responsible for the chronic asthma symptoms of dyspnea, wheezing, and chest tightness. It is hypothesized, but unproven, that inflammatory effects can lead to irreversible structural and functional airway changes. Early intervention with anti-inflammatory agents mitigates inflammatory changes, reverses airway obstruction, and may possibly prevent progression of airway remodeling. Current asthma guidelines recommend that initial management should be based on pretreatment assessments of asthma severity as determined by measures of clinical and spirometric impairment in individual patients; subsequent adjustments of pharmacotherapy and avoidance recommendations should be performed at regular follow-up visits and guided by frequent assessments of asthma control. Physicians and providers should continually educate asthmatic patients about proper use of asthma controller medications, avoidance of asthma triggers,...Continue Reading

References

Apr 1, 2000·Australian Family Physician·J Burdon
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Annemie L M Boehmer, Peter J F M Merkus
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Peter BraddingStephen T Holgate
Aug 29, 2006·Lancet·Sally E Wenzel

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Citations

Mar 30, 2010·Médecine sciences : M/S·Denis BedoretChristophe J Desmet
Nov 8, 2011·Respiratory Research·Umesh C S YadavSatish K Srivastava
Sep 30, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jorge F MasperoUNKNOWN P04139 Study Group
Feb 20, 2018·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Ziya SalturkYavuz Uyar

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