Abdominal aortic aneurysms and autosomal dominant polycystic kidney disease.

Journal of the American Society of Nephrology : JASN
Roser TorraA Darnell

Abstract

Although cases of autosomal dominant polycystic kidney disease (ADPKD) associated with abdominal aortic aneurysm have been repeatedly reported in the literature, no systematic studies of the aortas of these patients have been performed. In the study presented here, a sonographic study of the abdominal aorta in 139 ADPKD patients and in 149 healthy family members was carried out. For both groups, an increase in aortic diameter related to age and sex, (being wider in men than women) was found. In ADPKD patients, neither a wider aortic diameter nor a higher prevalence of abdominal aortic aneurysms could be found in any age group. It was concluded that, although these patients are prone to develop aortic aneurysms because of hypertension and associated connective tissue disorders, the presence of abdominal aortic aneurysms should be questioned as a frequent feature of ADPKD.

Citations

Jul 28, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sabrine HassaneMarco C DeRuiter
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N HateboerD Ravine
Mar 27, 2009·Nature Reviews. Nephrology·Tevfik Ecder, Robert W Schrier
Apr 26, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C DenneS Burdach

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