Abstract
Fat radiodensity, as measured by fat attenuation on computed tomography (CT), has emerged as a potential biomarker of "fat quality." We sought to characterize the relationship between fat radiodensity and quantity in subcutaneous, visceral, and intermuscular fat depots, and its role in inflammation, insulin resistance, and metabolic syndrome (MetS). We studied 1511 individuals from the Multi-Ethnic Study of Atherosclerosis who underwent CT for measurement of regional fat distribution and radiodensity, along with biomarker assessments and adjudication of incident metabolic syndrome (MetS). Linear, logistic and Cox regression analyses were used to measure association between fat radiodensity and (1) fat quantity, (2) biomarkers of cardiometabolic dysfunction, and (3) both prevalent and incident MetS. In each fat depot, radiodensity was strongly and inversely associated with quantity (e.g., visceral fat radiodensity vs. quantity: ρ = -0.82, P < 0.01). After adjustment for age, sex and race, lower visceral fat radiodensity was associated with greater C-reactive protein, leptin and insulin, but lower adiponectin (P < 0.01 for all). After full adjustment for cardiovascular disease risk factors, visceral (but not subcutaneous or inter...Continue Reading
References
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Jan 28, 2004·Circulation·Scott M GrundyUNKNOWN National Heart, Lung, and Blood Institute
Dec 17, 2008·Diabetes·Magdalena PasaricaSteven R Smith
Dec 19, 2009·Obesity·Katherine SamarasReginald V Lord
Feb 4, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shingo BabaRichard L Wahl
Aug 11, 2011·PloS One·Sonia S AnandArya M Sharma
Aug 13, 2011·Obesity·Morvarid KabirJoyce M Richey
Sep 20, 2012·JAMA : the Journal of the American Medical Association·Ian J NeelandJames A de Lemos
Jan 24, 2013·JAMA : the Journal of the American Medical Association·Ian J NeelandJames A de Lemos
May 15, 2013·JACC. Cardiovascular Imaging·Klara J RosenquistCaroline S Fox
May 24, 2013·Adipocyte·Tae-Hwa Chun
May 29, 2013·The American Journal of Cardiology·Matthew A AllisonJoao A Lima
May 6, 2014·Cell Reports·Isabelle K VilaDominique Langin
Aug 30, 2014·Journal of the American Heart Association·Nicholas J AlveyCaroline S Fox
Sep 23, 2014·Nature Communications·Miyako TanakaYoshihiro Ogawa
Nov 9, 2014·Obesity Surgery·Martin TorrianiElaine W Yu
Dec 3, 2014·JACC. Cardiovascular Imaging·Ravi V ShahMatthew A Allison
Dec 19, 2014·Obesity·Adriana L OliveiraMartin Torriani
Jun 11, 2015·The Journal of Clinical Endocrinology and Metabolism·Aaron J YeohCaroline S Fox
Citations
Jan 30, 2018·Diabetes, Obesity & Metabolism·Prince DadsonPirjo Nuutila
Dec 25, 2019·Obesity·Curtis TilvesIva Miljkovic
Jun 14, 2019·Obesity Surgery·Gian Franco AdamiRenzo Cordera
Dec 22, 2017·Journal of the Endocrine Society·Ilaria BarchettaMaria Gisella Cavallo
Jul 6, 2020·Alimentary Pharmacology & Therapeutics·Maryam EbadiAldo J Montano-Loza
Feb 13, 2019·BMC Medical Imaging·Louis Mullie, Jonathan Afilalo
Jul 1, 2020·AJR. American Journal of Roentgenology·Perry J PickhardtRonald M Summers
Feb 9, 2019·Environment International·M W DzierlengaM P Longnecker
Sep 14, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Prince DadsonPirjo Nuutila
Mar 2, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Perry J PickhardtRonald M Summers
Sep 1, 2018·Urologic Oncology·Ari P BernsteinJoshua M Stern
Sep 15, 2018·Obesity Research & Clinical Practice·Chantal A Vella, Matthew A Allison
Jun 23, 2021·European Radiology·Eun Ji LeeSoon Hyo Kwon
May 18, 2021·Obesity·Morgana Mongraw-ChaffinLynne E Wagenknecht
Jul 23, 2021·Psychosomatic Medicine·Erin DelkerMatthew A Allison