Abdominal hypertension and liver dysfunction in intensive care unit patients: an "on-off" phenomenon?

Transplantation Proceedings
L DalfinoNicola Brienza

Abstract

Intra-abdominal hypertension (IAH) can affect liver hemodynamics but it is not known if has a significant clinical impact on liver function. The aim of this study was to investigate the relationship between IAH and liver function. A prospective study was performed in 110 adult intensive care unit (ICU) patients. Intra-abdominal pressure (IAP) was measured on admission and every other day, and liver sequential organ failure assessment (SOFA) score was collected whenever IAP was measured. IAH was defined by a IAP >or= 10 mm Hg, and liver dysfunction was defined by a hepatic SOFA score >or= 2. An overall IAH incidence of 56.3% was found (n = 62). Thirty-three patients presented a liver SOFA score >or= 2, with an overall incidence of 30%. Liver SOFA score of the group of patients with abdominal hypertension was higher than in group of patients without abdominal hypertension. (0.8 +/- 1.05 vs 0.4 +/- 0.7; P < .05), but IAH and liver dysfunction were not significantly associated (chi2 = 2.03; P = .15). When the whole sample was divided according to the worst IAP score (IAP < 10, IAP between 10 and 15, and IAP > 15), the corresponding liver dysfunction scores in the three groups were 0.35 +/- 0.6, 0.74 +/- 1, and 1.2 +/- 1.3, respecti...Continue Reading

References

Apr 1, 1977·The Journal of Surgical Research·I J Sarfeh, J A Balint
Sep 1, 1983·The Journal of Trauma·M E GottliebD M Shah
Dec 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gianni BiancofioreFranco Mosca
Feb 6, 2004·Intensive Care Medicine·Manu L N G MalbrainLuciano Gattinoni
Aug 18, 2004·Anaesthesia·J D Hunter, Z Damani

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Citations

Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Gregory P VictorinoJavid Sadjadi
Mar 15, 2012·The Surgical Clinics of North America·Koen AmelootManu L N G Malbrain
Jan 1, 2007·Acta Clinica Belgica·J Wauters, A Wilmer
Jan 18, 2018·Folia medica·Raina G ArdashevaAthanas D Krustev

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