PMID: 2492008Jan 1, 1989Paper

Abdominal intratesticular islet-xenograft survival in rats

Diabetes
H SelawryD Bellgrau

Abstract

We investigated the survival of islet xenografts in the abdominal testes of normal, diabetes-resistant ACl and Wistar-Lewis (W-L) and in diabetes-prone BB/Wor rats. Islets were isolated from hamster donors, and after a period in tissue culture, they were injected into the abdominal testes of diabetic rats. Postoperatively, the rats were divided into two treatment groups. Four ACl rats received antilymphocyte serum (ALS) injections over a period of 30 days, and 13 ACl, 15 W-L, and 13 BB/Wor rats were given cyclosporin (CsA) according to the following regimen: 25 mg/kg i.p. for 7 days, then 7 mg/kg i.p. for 23 days. On day 30, immunosuppression was stopped. The results showed that none of the ALS-treated ACl rats remained normoglycemic for greater than 9 days. However, CsA therapy resulted in an extended mean duration of normoglycemia in the ACl and W-L rats of 160.0 +/- 36.0 and 131.0 +/- 31 days, respectively. By contrast, the mean duration of normoglycemia in the BB/Wor rats was 33.0 +/- 4.0 days. Furthermore, all of the BB/Wor rats reverted to diabetes after CsA was stopped. Therefore, the concomitant administration of an antigenic islet xenograft with CsA led to a state of unresponsiveness only in diabetes-resistant but not ...Continue Reading

Citations

Aug 21, 2013·Current Diabetes Reports·Sophie VériterDenis Dufrane
Dec 21, 2002·Transplantation Proceedings·L A Zuraff-PerrymanD Bellgrau
Jul 23, 1999·Annals of the New York Academy of Sciences·G R RayatG S Korbutt
Nov 8, 2003·Immunological Investigations·Jannette M DufourDwaine F Emerich
Jan 9, 2003·Expert Opinion on Biological Therapy·Dwaine F Emerich
Dec 19, 2006·Transplantation Proceedings·Z Z YinS Chen
Jan 8, 2004·Xenotransplantation·Jannette M DufourGregory S Korbutt
Aug 13, 2003·Cell Transplantation·Dwaine F EmerichCraig R Halberstadt
Oct 19, 1995·Nature·D BellgrauR C Duke
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isam W NasrZhenhua Dai

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