PMID: 9422573Jan 9, 1998Paper

Abdominal irradiation in unilateral nephroblastoma and its impact on local control and survival

International Journal of Radiation Oncology, Biology, Physics
M FlentjeR Ludwig

Abstract

The influence of abdominal radiotherapy was analyzed in 122 patients with unilateral Wilms tumor eligible for local irradiation according to postoperative SIOP-stage. 122 of 454 children with Wilms tumor diagnosed between January 1989 and March 1994 in Germany were eligible for abdominal irradiation after preoperative chemotherapy and tumor resection according to SIOP9/GPOH protocol. There were 88 children with standard histology (SH; local Stage IIN+ and III) and 34 children with unfavorable histology (UH; anaplastic, clear cell and rhabdoid, local Stages II and III). Local irradiation was given postoperatively parallel to polychemotherapy according to protocol with appropriate dose reductions of Actinomycin D (dactinomycin) during the course of radiotherapy. Fifteen Gy to the tumor bed were prescribed in standard histology, with 30 Gy to regional lymph nodes, if histologically positive. Thirty Gy were given in unfavorable histology. Boost doses up to 15 Gy were possible for macroscopic residuals. Ages ranged between 6 months and 21 years (median 4.2 years). Only 98 of 122 eligible children were irradiated. Reasons for ommission of radiotherapy were: Stage III only due to intraoperative biopsy (n = 6), due to resected cava thr...Continue Reading

References

Jan 1, 1985·Medical and Pediatric Oncology·G J D'Angio
Mar 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M BurgersJ Lemerle
Jun 1, 1980·International Journal of Radiation Oncology, Biology, Physics·P N Jeal, R D Jenkin

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Citations

Oct 9, 2013·The Cochrane Database of Systematic Reviews·Sebastiaan L KnijnenburgMonique W M Jaspers
Jan 12, 2008·Nephron. Clinical Practice·Ali Varan
Mar 12, 2019·The Cochrane Database of Systematic Reviews·Esmee Cm KooijmansMargreet A Veening
Feb 25, 1999·Journal of Pediatric Hematology/oncology·L M PirichD O Walterhouse
Sep 6, 2019·Journal of Global Oncology·Atteby Jean-Jacques YaoCatherine Patte
May 18, 1999·Current Opinion in Oncology·H H LeeP A Merguerian

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