Abstract
Internal drainage of cerebrospinal fluid (CSF) to the abdominal cavity via a ventriculo-peritoneal shunt (VPS) is a procedure that is commonly used for the treatment of obstructive hydrocephalus. As this condition is often caused by brain tumors blocking the natural CSF pathways, a VPS, as an artificial anastomosis, can provide the means for tumor cells to be spread with the CSF. A review of the literature reveals 35 VPS-related abdominal metastases from pediatric brain tumors; 17 in patients aged 0-9 (group A) and 18 in patients aged 10-18 years (group B); the mean age of male patients was 10.5, and that of female patients, 7 years. The male-to-female ratio was 1.9 (group A 1.1, group B 3.5), and the mean interval between shunt operation and diagnosis of metastases, 16.7 months (group A 11.6, group B 22.6 months; boys 21.6, girls 7.5 months). During the observation period, 22/30=73.3% of the patients died (group A 13/15=86.7%, group B 9/15=60%; boys 13/21=61.9%, girls 9/9=100%); their mean survival time after shunting was 18.7 months (group A 15.7, group B 23.1 months; boys 25.5, girls 9 months). The four most common sources of metastases were germinomas (9 cases=25.7%; group A none, group B 9), medulloblastomas (8 cases=22.9%...Continue Reading
Citations
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