Abdominal MR angiography performed using blood pool contrast agents: comparison of a new superparamagnetic iron oxide nanoparticle and a linear gadolinium polymer

AJR. American Journal of Roentgenology
C Nolte-ErnstingR W Günther

Abstract

We evaluated and compared two different experimental blood pool contrast agents for abdominal MR angiography in an animal model. In seven pigs, coronal T1-weighted three-dimensional fast field-echo images were obtained on a conventional 1.5-T MR imaging system before and after i.v. injection of the ultrasmall superparamagnetic iron oxide agent FeO-BPA. In another seven pigs, MR angiograms were acquired using the gadolinium polymer WIN 22181. Enhanced images were obtained 5-210 min after injection of FeO-BPA and 1-120 min after injection of WIN 22181. Both blood pool agents yielded detailed angiograms of the abdominal vascular tree when imaging lasted 2 min. In-plane running vessels were imaged without saturation effects and with equivalent maximum signal-to-noise ratios. Half the maximum signal-to-noise ratio was reached 150 min after injection of FeO-BPA, whereas this interval was approximately 70 min for the gadolinium polymer. Because of these different imaging half-life periods, the effective diagnostic window provided by FeO-BPA was six to eight times longer than that of WIN 22181. In the liver, the vascular T1 shortening and the parenchymal T2* effect of FeO-BPA complemented each other, resulting in an optimal contrast-to...Continue Reading

References

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Citations

May 9, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D NanzJ F Debatin
Jul 6, 2000·AJR. American Journal of Roentgenology·D WeishauptJ F Debatin
Dec 20, 2002·AJR. American Journal of Roentgenology·Elna-Marie LarssonFranz Ebner
Mar 13, 2013·Nanomedicine·Catherine A SchützUNKNOWN NanoImpactNet Consortium
Nov 15, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sunil N GandhiClaude B Sirlin
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ratchapol JenjobSu-Geun Yang
Mar 22, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J F Glockner
Jul 9, 2003·IEEE Transactions on Medical Imaging·Cornelis M van BemmelWiro J Niessen
Apr 6, 2002·Clinics in Liver Disease·Hoon Ji, Pablo R Ros
Sep 22, 2015·Chemical Society Reviews·Hamed AramiKannan M Krishnan
Dec 6, 2000·Journal of Magnetic Resonance Imaging : JMRI·M SaeedC B Higgins
Sep 27, 2016·International Journal of Molecular Medicine·Yu-Dong XiaoShun-Ke Zhou

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