Abstract
Abdominal obesity is often associated with a constellation of comorbidities that include central adiposity, insulin resistance, dyslipidemia, and hypertension. Clinical evaluations should include a measurement of waist circumference, which is a good marker of abdominal obesity. Abdominal obesity is closely associated with an elevated outflow of free fatty acids from the visceral fat compartment and dysregulation of adipokine expression, accompanied by increased inflammation. The most serious consequences of abdominal obesity are coronary heart disease and stroke. It is also associated, however, with polycystic ovary syndrome and hepatic steatosis. Weight reduction and increased physical activity should be recommended to patients with a high waist circumference. Patients with abdominal obesity and other classic risk factors are at high cardiovascular risk and require strict monitoring of their blood pressure, LDL-c, and blood glucose. New pharmacological strategies might help manage both abdominal obesity and its metabolic consequences.
References
Jun 2, 2000·Gastroenterology·V RatziuT Poynard
Jul 13, 2000·Circulation·I LemieuxJ P Després
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jan 28, 2004·Circulation·Scott M GrundyUNKNOWN National Heart, Lung, and Blood Institute
Feb 6, 2004·Circulation·Scott M GrundyUNKNOWN American Diabetes Association
Feb 28, 2004·Diabetes Care·Latha PalaniappanUNKNOWN Insulin Resistance Atherosclerosis Study
May 26, 2004·Archives of Internal Medicine·Gang HuUNKNOWN DECODE Study Group
Jun 4, 2004·The New England Journal of Medicine·Ram WeissSonia Caprio
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Yong-Ming LiuKarine Clément
Jun 18, 2004·The New England Journal of Medicine·Samuel KleinB Selma Mohammed
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Boris HanselAnatol Kontush
Jul 9, 2005·Journal of Applied Physiology·Cris A SlentzWilliam E Kraus
Jun 15, 2007·Diabetes Care·Louis GuizeAthanase Benetos
Oct 11, 2007·Obesity·Tomohiro OkuraKiyoji Tanaka