Abdominal Obesity in Comparison with General Obesity and Risk of Developing Rheumatoid Arthritis in Women.

The Journal of Rheumatology
Nathalie MarchandBing Lu

Abstract

Being overweight or obese increases rheumatoid arthritis (RA) risk among women, particularly among those diagnosed at a younger age. Abdominal obesity may contribute to systemic inflammation more than general obesity; thus, we investigated whether abdominal obesity, compared to general obesity, predicted RA risk in 2 prospective cohorts: the Nurses' Health Study (NHS) and NHS II. We followed 50,682 women (1986-2014) in NHS and 47,597 women (1993-2015) in NHS II, without RA at baseline. Waist circumference (WC), BMI, health outcomes, and covariate data were collected through biennial questionnaires. Incident RA cases and serologic status were identified by chart review. We examined the associations of WC and BMI with RA risk using time-varying Cox proportional hazards models. We repeated analyses restricted to age ≤ 55 years. During 28 years of follow-up, we identified 844 incident RA cases (527 NHS, 317 NHS II). Women with WC > 88 cm (35 in) had increased RA risk (HR 1.22, 95% CI 1.06-1.41). A similar association was observed for seropositive RA, which was stronger among young and middle-aged women. Further adjustment for BMI attenuated the association to null. In contrast, BMI was associated with RA (HRBMI ≥ 30 vs < 25 1.33, 9...Continue Reading

References

Nov 15, 1992·Annals of Internal Medicine·C M WeyandJ J Goronzy
Feb 1, 1992·Journal of Applied Physiology·R RossR Guardo
Jan 1, 1991·Nutrition and Cancer·J L Freudenheim, S L Darrow
Oct 1, 1994·International Journal of Epidemiology·A M WolfW C Willett
Jan 1, 1993·Medicine and Science in Sports and Exercise·B E AinsworthR S Paffenbarger
Jul 1, 1995·Annals of Epidemiology·E W KarlsonM H Liang
Feb 27, 2004·The American Journal of Clinical Nutrition·Ian JanssenRobert Ross
Mar 8, 2005·Clinical Rheumatology·Jaime Calvo-AlénVicente Rodríguez-Valverde
Jul 5, 2005·Atherosclerosis·Barbara ThorandUNKNOWN KORA Group
Jun 6, 2006·The American Journal of Medicine·Karen H CostenbaderElizabeth W Karlson
Feb 27, 2010·Obesity·Malin AlvehusTommy Olsson
Jun 18, 2011·Medicine and Science in Sports and Exercise·Barbara E AinsworthArthur S Leon
Apr 20, 2012·The Journal of Nutrition·Stephanie E ChiuveWalter C Willett
Apr 20, 2012·Arthritis Care & Research·Cynthia S CrowsonSherine E Gabriel
Nov 20, 2013·Current Opinion in Rheumatology·M Kristen DemoruelleV Michael Holers
Apr 16, 2014·Arthritis Research & Therapy·Lena InnalaSolveig Wållberg-Jonsson
Jul 25, 2014·Annals of the Rheumatic Diseases·Bing LuElizabeth W Karlson
Sep 26, 2015·International Journal of Epidemiology·Mingyang SongEdward L Giovannucci
Nov 30, 2016·Arthritis Research & Therapy·Lotta Ljung, Solbritt Rantapää-Dahlqvist
Dec 2, 2017·International Journal of Cancer. Journal International Du Cancer·Kyu Rae LeeMi Hae Seo

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