Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in rats.

Peptides
Andreas StengelYvette Taché

Abstract

Abdominal surgery-induced postoperative gastric ileus is well established to induce Fos expression in specific brain nuclei in rats within 2-h after surgery. However, the phenotype of activated neurons has not been thoroughly characterized. Nesfatin-1 was recently discovered in the rat hypothalamus as a new anorexigenic peptide that also inhibits gastric emptying and is widely distributed in rat brain autonomic nuclei suggesting an involvement in stress responses. Therefore, we investigated whether abdominal surgery activates nesfatin-1-immunoreactive (ir) neurons in the rat brain. Two hours after abdominal surgery with cecal palpation under short isoflurane anesthesia or anesthesia alone, rats were transcardially perfused and brains processed for double immunohistochemical labeling of Fos and nesfatin-1. Abdominal surgery, compared to anesthesia alone, induced Fos expression in neurons of the supraoptic nucleus (SON), paraventricular nucleus (PVN), locus coeruleus (LC), Edinger-Westphal nucleus (EW), rostral raphe pallidus (rRPa), nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM). Double Fos/nesfatin-1 labeling showed that of the activated cells, 99% were nesfatin-1-immunoreactive in the SON, 91% in the LC, 8...Continue Reading

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Citations

Jun 4, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andreas StengelYvette Taché
Jul 8, 2014·Current Opinion in Pharmacology·Andreas Stengel, Yvette Taché
Jan 10, 2012·Neuropeptides·Artur PałaszGrzegorz Bajor
Aug 16, 2011·Medical Hypotheses·J F SaldanhaD Mafra
Jun 29, 2010·Regulatory Peptides·Andreas Stengel, Yvette Taché
May 17, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A StengelY Taché
Jun 16, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A StengelY Taché
Aug 29, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A StengelY Taché
May 11, 2011·Brain Research·Miriam Goebel-StengelYvette Taché
Jun 26, 2013·Psychoneuroendocrinology·Tobias HofmannBurghard F Klapp
Jan 18, 2017·Journal of Neurogastroenterology and Motility·Philip Prinz, Andreas Stengel
Dec 1, 2012·Balsaeng'gwa saengsig·Jinhee Kim, Hyunwon Yang
Sep 14, 2018·Frontiers in Endocrinology·Andreas Stengel, Yvette Taché
Jan 27, 2019·Balsaeng'gwa saengsig·Sojung Sun, Hyunwon Yang
Feb 17, 2019·Journal of Neural Transmission·Artur PałaszRyszard Wiaderkiewicz
May 10, 2017·Balsaeng'gwa saengsig·Sojeong SeonHyunwon Yang
Dec 3, 2020·Frontiers in Psychiatry·Alison Accarie, Tim Vanuytsel
Aug 1, 2021·General and Comparative Endocrinology·Krittika DotaniaUmesh Rai

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