Abeliaside, a new phenolic glucoside from Abelia triflora

Natural Product Research
Areej Mohammad Al-TaweelAbdul Malik

Abstract

A new phenolic glucoside, abeliaside, along with four known compounds, 5,6,7,4'-tetrahydroxy flavones, caffeic acid, 4-O-caffeoylquinic acid and caffeic acid glucoside, was isolated from the leaves of Abelia triflora R. Br. (Caprifoliaceae). The structure of the new compound was elucidated by different spectroscopic techniques. Compounds 1-5 were assayed for their anticancer activities against two cancerous human cell lines, MCF-7 and PC-3 cells, and normal Vero cell line using the crystal violet staining method. From the results it could be seen that caffeic acid possessed the highest anticancer effect against MCF-7 (IC50: 17 μg/mL) and PC-3 (IC50: 20.1 μg/mL) compared to vinblastine sulphate as reference drug (IC50: 4.6, 2.8 μg/mL). The other compounds showed weak anticancer activity on both cell lines.

References

Aug 5, 2000·Journal of Natural Products·L TomassiniM F Cometa
Apr 20, 2002·Chemical & Pharmaceutical Bulletin·Masao ToyotaYoshinori Asakawa
Jan 1, 1989·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K SaotomeM Umeda
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H ItagakiM Umeda

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Citations

May 12, 2018·Journal of Chromatographic Science·Nourah Zoman AlzomanRuba Mahmoud Al-Sabbagh

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Methods Mentioned

BETA
NMR

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