Aberrant Bcl6 protein expression in mantle cell lymphoma

The American Journal of Surgical Pathology
Francisca I CamachoMiguel A Piris

Abstract

Mantle cell lymphoma is routinely considered as a Bcl6-negative B-cell lymphoma carrying the translocation t(11;14). Here we describe a series of five Bcl6-positive mantle cell lymphoma cases, including three classic and two blastoid variants. The proliferative index of these cases, measured with the Ki-67 antibody, was slightly higher than in Bcl6-negative mantle cell lymphoma cases (32.2 vs. 23.7%) Bcl6 expression was associated with translocations involving 3q27 in four of the five cases and an extra copy of the BCL6 gene in the fifth. A mutational study of the major mutational cluster in the BCL6 gene revealed no increased mutation rate, except in one case. One of the three cases displayed a high mutational index in the IgVH gene, suggesting exposure to a germinal center microenvironment. Chromosomal alterations involving 3q27 seem to be responsible for this increased Bcl6 expression, which needs to be considered when Bcl6 is used in lymphoma diagnosis.

References

Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·A MigliazzaR Dalla-Favera
May 1, 1997·Annals of Hematology·I MiuraA B Miura
Jul 17, 1998·The American Journal of Pathology·L Quintanilla-MartinezM Raffeld
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·L PasqualucciR Dalla-Favera
Jan 5, 2002·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·J L FraterR R Tubbs
Jun 20, 2002·European Journal of Haematology·Mia ThorséliusRichard Rosenquist
Aug 7, 2002·American Journal of Clinical Pathology·Zach LiuJames Weisberger
Oct 24, 2002·Blood·Margarita Sánchez-BeatoMiguel A Piris
Feb 13, 2003·American Journal of Clinical Pathology·Henry Y DongJames Weisberger

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Citations

Oct 15, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gabriela GualcoCarlos E Bacchi
Mar 21, 2007·Journal of Clinical Pathology·Sonam Prakash, Steven H Swerdlow
Oct 30, 2013·Medical Molecular Morphology·Toshiki YamadaHitoshi Iwata
Apr 10, 2008·Leukemia & Lymphoma·John Anastasi
Nov 30, 2010·Best Practice & Research. Clinical Haematology·Brunangelo FaliniStefano A Pileri
Jan 22, 2008·Human Pathology·Dorothée Bouron-Dal SoglioJean-Christophe Fournet
Apr 16, 2008·British Journal of Haematology·Pedro Jares, Elías Campo
Jun 4, 2008·Histopathology·U ZanettoC M Bacon
Sep 22, 2012·British Journal of Haematology·P McKayUNKNOWN British Committee for Standards in Haematology
Apr 26, 2008·Human Pathology·Lynnette K TumwineStefano A Pileri
Aug 31, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ting-Yun LiuChung-Wu Lin
Apr 25, 2013·The American Journal of Dermatopathology·Anna Maria CesinaroMarina Milani
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giorgio CattorettiBachir Alobeid
Jun 20, 2017·Histopathology·Marco PizziElena Sabattini
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Russell A HigginsMarsha C Kinney
Aug 8, 2008·Archives of Pathology & Laboratory Medicine·Vathany SriganeshanDavid J Weissmann
Feb 23, 2021·Case Reports in Gastroenterology·Ahmed M Ahmed, Sima Vossough

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