Aberrant DNA methylation of apoptotic signaling genes in patients responsive and nonresponsive to therapy for cervical carcinoma

American Journal of Obstetrics and Gynecology
Patimaporn ChaopatchayakulTemduang Limpaiboon

Abstract

We sought to investigate CpG-island methylation profiling of apoptotic genes apoptotic protease activating factor 1, caspase 8, death-associated protein kinase (DAPK), tumor necrosis factor receptor superfamily member 6 (FAS), Survivin, and tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and its role in resistance to therapy in cervical cancer (CXCA). Methylation status was performed in 85 CXCA patients comprising therapeutic nonresponses and responses using methylation-specific polymerase chain reaction. Methylation frequency of DAPK and FAS showed a statistically significant difference between therapeutic nonresponses and responses. Concurrent methylation of multiple apoptotic genes was a preferential event in CXCA. Moreover, concerted methylation of pair genes was observed in DAPK, FAS, and tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and found only in nonresponses. Aberrant methylation of apoptotic signaling genes results in acquired resistance to therapy. Detection of methylation in apoptotic signaling genes is potentially useful as a molecular predictive marker for strategic planning of treatment efficacy and evaluation of therapeutic outcome in CXCA, leading to an improvement of p...Continue Reading

References

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T ItoA Suzuki
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P G Rose
Apr 18, 2002·Japanese Journal of Clinical Oncology·Vanchai VatanasaptPatravoot Vatanasapt
Jan 2, 2003·Nature Reviews. Cancer·Dario C Altieri
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie Si LiuHextan Yuen-Sheung Ngan
Nov 10, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jens M TeodoridisRobert Brown
Oct 6, 2005·Cancer Research·Jens M TeodoridisRobert Brown
Dec 20, 2005·The Journal of Pathology·Peter J F SnijdersChris J L M Meijer
Apr 20, 2006·Cancer Letters·N K SahP S Bisen
Apr 28, 2006·International Journal of Cancer. Journal International Du Cancer·Frank ChristophMark Schrader
Jun 8, 2006·Annual Review of Biochemistry·Shani Bialik, Adi Kimchi
Jun 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Allison M HunterRobert G Korneluk
Nov 22, 2007·Gynecologic Oncology·Marc Steben, Eliane Duarte-Franco
Dec 18, 2007·Heart Failure Reviews·Mehregan Movassagh, Roger S-Y Foo
Apr 1, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M S KimS H Lee
May 23, 2008·Cytokine & Growth Factor Reviews·Avi Ashkenazi
Aug 30, 2008·Cancer Treatment Reviews·Elza C de Bruin, Jan Paul Medema

❮ Previous
Next ❯

Citations

Feb 24, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Roel H Wilting, Jan-Hermen Dannenberg
Jan 1, 2013·Cells·Eric HervouetPierre-François Cartron
Jan 11, 2018·Science China. Life Sciences·Hui LyuBolin Liu
Oct 6, 2017·Briefings in Bioinformatics·Xiaoqiang Sun, Bin Hu
Jun 30, 2019·Cancers·Mohammed I Y Elmallah, Olivier Micheau
Apr 26, 2019·Journal of Cellular Physiology·Yasamin PahlavanAlireza Khabbazi
Jan 10, 2021·Seminars in Cancer Biology·Lei GuoYun Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.