Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis

Frontiers in Cell and Developmental Biology
Yang PengNan-Shan Zhong

Abstract

Dilation of bronchi and bronchioles caused by destruction and excessive epithelial remodeling is a characteristic feature of bronchiectasis. It is not known how epithelial progenitor cells contribute to these pathologic conditions in peripheral airways (bronchioles) in bronchiectasis. We aimed to explore the expression levels of signature airway progenitor cells in the dilated bronchioles in patients with bronchiectasis. We obtained the surgically resected peripheral lung tissues from 43 patients with bronchiectasis and 33 control subjects. Immunostaining was performed to determine the expression patterns of thyroid transcription factor-1 (TTF-1, for labeling progenitor cells in distal airways), P63 (basal cells), club cell 10 kDa protein (CC10, club cells), and surfactant protein C (SPC, alveolar type II epithelial cells) in epithelium or sub-epithelium. Here, we reported significantly lower percentage of TTF-1+ cells and CC10+ cells, and higher percentage of P63+ cells within the epithelium of dilated bronchioles compared with control bronchioles. In airway sub-epithelium of the dilated bronchioles, epithelial hyperplasia with disarrangement of TTF-1+ cells yielded cuboidal (100%) and columnar (93.0%) type among bronchiectasi...Continue Reading

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Citations

Aug 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Khosbayar LkhagvadorjMachteld N Hylkema

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Methods Mentioned

BETA
fluorescence microscopy
bronchoalveolar lavage

Software Mentioned

SPSS
GraphPad Prism

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