Aberrant expression of angiopoietin-like proteins 1 and 2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Zhenteng LiuQinglan Qu

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with obesity, insulin resistance, hyperandrogenism, alterations in ovarian angiogenesis and impaired oocyte competence. Emerging evidence demonstrates that angiopoietin-like protein 1 (ANGPTL1) and angiopoietin-like protein 2 (ANGPTL2) have an important influence on angiogenesis, androgen biosynthesis, insulin resistance and adipocytes function. In this study, we set out to determine the potential relationship between ANGPTL1, ANGPTL2 and oocyte competence in PCOS through analyzing the expression levels and dynamic pattern of the two genes in cumulus cells (CCs) during different phases of nuclear maturation of PCOS patients and control groups undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer. We found that the relative abundance of ANGPTL1 and ANGPTL2 transcripts in CCs from patients with PCOS showed dynamic changes during oocyte maturation. Specifically, their expressions were increased significantly at the Metaphase II stage. In summary, the present novel evidence indicates that the expression patterns of ANGPTL1 and ANGPTL2 mRNAs are disordered during oocyte maturation in PCOS, which were potent...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yoshiaki KubotaToshio Suda
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Jan 22, 2008·Trends in Cardiovascular Medicine·Tai HatoYuichi Oike
Jun 22, 2010·Fertility and Sterility·Konstantinos G Michalakis, James H Segars
Mar 12, 2013·Fertility and Sterility·Daniel A Dumesic, Joanne S Richards
Apr 23, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Xin HuangLili Chen
Oct 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Richard S LegroUNKNOWN Endocrine Society
Apr 22, 2014·Trends in Endocrinology and Metabolism : TEM·Tsuyoshi KadomatsuYuichi Oike
Jan 23, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zhenteng LiuQinglan Qu
May 23, 2015·Archives of Medical Research·Zhiqing WangZhurong Luo

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Citations

Mar 3, 2018·Journal of Assisted Reproduction and Genetics·M G Da BroiP A Navarro
Jul 29, 2021·Journal of Human Reproductive Sciences·Luxmipratha RajendiranThyagaraju Chitra

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