Aberrant expression of CD95 and CD69 molecules among CD56 cells in women with endometriosis

American Journal of Reproductive Immunology : AJRI
Audrone EidukaiteVytas Tamosiunas

Abstract

Activated lymphocytes can be eliminated by Fas/Fas ligand (FasL)-induced cell death. Endometrial cells express FasL. The aim of our study was to determine the expression of CD56+ cells (natural killer and natural killer T cells) Fas antigen CD95 and the early activation molecule CD69 in the peritoneal fluid of women with endometriosis. Two-colour flow cytometry was used. In the early stages of endometriosis, more CD56+ cells expressed CD69 and CD95 molecules when compared with the control group. However, in case of severe endometriosis the percentage of CD95+CD56+ cells in peritoneal fluid was similar to that of the control group, but the expression of CD69 molecules remained high. Because of Fas/FasL mechanisms, in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated, thus providing conditions for the survival of ectopic endometrial cells and the development of the disease.

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Citations

Apr 21, 2009·Journal of Reproductive Immunology·N TariverdianP C Arck
Jun 25, 2015·American Journal of Reproductive Immunology : AJRI·Uma ThiruchelvamCliona O'Farrelly
Jun 14, 2016·BioMed Research International·InCheul JeungMee-Ran Kim

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