Aberrant expression of cell cycle regulators in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Alexandar TzankovS Dirnhofer

Abstract

The characteristic Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma, although highly positive for proliferation markers, do not accumulate to excessive cell numbers. These cells are characterized by abortive mitotic cycles, leading to multinucleation or cell death in mitosis. We have previously described high expression of G1-phase cyclins in classical Hodgkin's lymphoma, which could explain the high percentage of cells staining for proliferation markers. To further our understanding of proliferation control in classical Hodgkin's lymphoma, we extended our immunohistochemical analysis to the main S-phase cyclin, cyclin A, and its regulators p21CIP1 and p27KIP1. Expression of proliferating cell nuclear antigen (PCNA) was used as an additional marker for cells being in either S- or G2-phase. In 47% (112/239) of classical Hodgkin's lymphoma cases p21CIP1 was detected within a mean frequency of 15% positive Hodgkin's and Reed-Sternberg cells per case. Similarly, 47% (116/249) of the cases stained positively for p27KIP1 with a mean frequency of expression in Hodgkin's and Reed-Sternberg cells of 12%. In contrast, 90% of the cells in all 246 evaluable classical Hodgkin's lymphoma cases were positive for PCNA. In addit...Continue Reading

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Citations

Jan 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cecile MeierAlexandar Tzankov
Feb 2, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew L FeldmanWilliam R Macon
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Apr 30, 2009·Annual Review of Pathology·Roland SchmitzRalf Küppers
Dec 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Benjamin RengstlMartin-Leo Hansmann
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Mar 4, 2014·Asian Cardiovascular & Thoracic Annals·Sonia Baccari-EzzineHédia Ghrairi
Jan 13, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zenggang PanJi Yuan
Jan 27, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Alexandar TzankovStephan Dirnhofer
Aug 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alexandar TzankovStephan Dirnhofer
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Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexandar TzankovPhilip Went

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