Aberrant expression of erythropoietin in uterine leiomyoma: implications in tumor growth

American Journal of Obstetrics and Gynecology
Ryoko AsanoEtsuko Miyagi

Abstract

Myomatous erythrocytosis syndrome is a rare complication of uterine leiomyoma caused by erythropoietin (EPO) that is produced by tumor cells. We assessed the EPO expression in leiomyomas and investigated the effects of EPO on the tumor growth. Tissue samples were collected from 114 patients with uterine leiomyomas who underwent myomectomy or hysterectomy in Yokohama City University Hospital. From 17 patients, the corresponding normal myometrium was also collected. All samples were analyzed for EPO messenger RNA (mRNA) expression by real-time reverse transcription-polymerase chain reaction. EPO protein expression was determined by an enzyme-linked immunosorbent assay. The relationships between EPO expression and clinicopathological features were retrospectively analyzed using the patients' charts. Blood vessel density and maturity were assessed using hematoxylin-eosin staining and CD34 immunohistochemistry. EPO mRNA expression was detected in 108 of 114, or 95%, of the leiomyomas. The mean EPO mRNA expression in the leiomyoma was higher than the corresponding normal myometrium (3836 ± 4122 vs 1455 ± 2141; P = .025 by Wilcoxon rank test). The EPO mRNA expression in the leiomyomas varied extensively among samples, ranging from und...Continue Reading

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Citations

May 15, 2019·Obstetrics and Gynecology·Brian GordonStuart Schroff
May 29, 2019·Obstetrics and Gynecology·Brian GordonStuart Schroff
Aug 20, 2021·Journal of Obstetrics and Gynaecology of India·Kusumam Vilangot NhalilK P Shana Rahman
Mar 25, 2019·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Justin MuiHarold Hunt

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