Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis

Human Reproduction
Sakthivignesh Ponandai-SrinivasanP G L Lalitkumar

Abstract

Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)? We identified aberrant gene expression signatures associated with malignant transformation in a small subgroup of women with ovarian endometriosis. Epidemiological studies have shown an increased risk of EAOC in women with ovarian endometriosis. However, the cellular and molecular changes leading to EAOC are largely unexplored. CD73+CD90+CD105+ multipotent stem cells/progenitors (SC cohort) were isolated from endometrium (n = 18) and endometrioma (n = 11) of endometriosis patients as well as from the endometrium of healthy women (n = 14). Extensive phenotypic and functional analyses were performed in vitro on expanded multipotent stem cells/progenitors to confirm their altered characteristics. Aberrant gene signatures were also validated in paired-endometrium and -endometrioma tissue samples from another cohort (Tissue cohort, n = 19) of endometriosis patients. Paired-endometrial and -endometriotic biopsies were obtained from women with endometriosis (ASRM stage III-IV) undergoing laparoscopic surgery. Control endometria were obtained from healthy volunteers. Isolated CD73+CD90+CD105+ SC were evaluated for the prese...Continue Reading

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Citations

Sep 9, 2020·Human Reproduction·Sakthivignesh Ponandai-SrinivasanKristina Gemzell-Danielsson
May 31, 2019·Molecular Genetics & Genomic Medicine·Dandan WangQing Yang
Jan 8, 2020·Stem Cell Research & Therapy·Suzanna QueckbörnerLindsay C Davies
Apr 25, 2019·International Journal of Molecular Sciences·Konstantinos SapalidisIsaak Kesisoglou

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