Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

Acta Dermato-venereologica
Weilong ZhongXia Dou

Abstract

Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in chronic itch and inflammation. This study investigated the mRNA levels and immunoreactivity of the nerve growth factor, IL-31, thymic stromal lymphopoietin, and endothelin axes in both lesional and perilesional skin in prurigo nodularis by using quantitative real-time PCR and immunohistochemistry studies. The nerve growth factor high-affinity receptor tyrosine kinase receptor A was upregulated while the low affinity receptor p75 neurotrophin receptor was downregulated in prurigo nodularis lesions. Downregulated expression of IL-31/IL-31 receptor A and endothelin-3/endothelin receptor B and upregulation of thymic stromal lymphopoietin receptor were found in prurigo nodularis lesions. Aberrant expression of nerve growth factor, IL-31, thymic stromal lymphopoietin and endothelin axes was found in prurigo nodularis lesions, especially in the epidermis, indicating the importance of keratinocytes in prurigo nodularis pathogenesis.

Citations

Feb 20, 2020·The New England Journal of Medicine·Sonja StänderChristophe Piketty
Sep 3, 2019·The Journal of Investigative Dermatology·Lai-San WongChih-Hung Lee
Mar 28, 2021·The Journal of Investigative Dermatology·Micah BelzbergShawn G Kwatra
Apr 4, 2021·Vaccines·Simone GarcovichGiampiero Girolomoni
Jul 23, 2021·Expert Opinion on Biological Therapy·Svenja MüllerSonja Ständer

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