PMID: 8941971Sep 1, 1996Paper

Aberrant expression of immunoglobulin mRNA in bovine leukemia virus-infected cattle

Veterinary Immunology and Immunopathology
M R Teutsch, H A Lewin

Abstract

Our objective was to determine whether bovine leukemia virus (BLV) integration and expression affect the expression of host genes that function in immune responses and cell proliferation. Freshly isolated mlgM+ cells obtained from BLV-infected cows with persistent lymphocytosis (PL) expressed increased Ig-mu mRNA and decreased mRNA for Ig-lambda relative to infected and uninfected animals that had normal peripheral lymphocyte counts. In contrast, there was no correlation between BLV-infection status and expression of major histocompatibility complex (Mhc) Class I or Class II genes. The induction of BLV expression in mlgM+ cells from animals with PL did not affect significantly the levels of Mhc Class I, Class II, Ig-mu or Ig-lambda mRNA. Phorbol ester-induced c-fos mRNA expression was greater in the BLV-infected cell line BL3 degrees than the uninfected parental cell line BL3 degrees. However, the level of c-fos expression did not appear different compared with its induction in peripheral blood B cells from seronegative animals and animals with PL. We conclude that the BLV early and late phase proteins have no effect on Ig or Mhc mRNA levels, but that freshly isolated mlgM+ cells from PL animals constitutively express increased...Continue Reading

References

Sep 1, 1991·European Journal of Immunology·P J GriebelJ D Reynolds
Dec 1, 1989·Veterinary Immunology and Immunopathology·M J RomanoH A Lewin
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M FujiiI M Verma
Mar 1, 1995·International Immunology·M TeutschH W Wortis

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