PMID: 8962718Jan 1, 1996Paper

Aberrant FGF-2, FGF-3, FGF-4 and C-erb-B2 gene copy number in human ovarian, breast and endometrial tumours

Growth Factors
J F SchmittM T Hearn

Abstract

The important role of oncogene amplification and tumour suppressor gene deletion in human tumours is becoming increasingly apparent. However, extensive screening of human tumours is required before the prognostic significance of such genetic abnormalities can be fully appreciated. The present investigation describes a rapid non-radioactive and largely automated procedure for the analysis of aberrant gene copy number in large numbers of tissue samples of different human tumours. This procedure is based on the sequential use of the polymerase chain reaction (PCR) and high performance ion exchange liquid chromatography (HPIEX). Using this rapid PCR/HPIEX technique, we have identified amplification and deletion of the FGF-2 gene and the FGF-3, FGF-4 and c-erb-B2 oncogenes in human tumours of the breast, ovary and endometrium. Comparison of the data with tumour pathology has revealed possible associations between aberrant gene copy number and tumour type, invasiveness and metastases.

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Citations

Mar 21, 2001·Atherosclerosis·L MatturriJ Milei
Dec 30, 1996·Journal of Biochemical and Biophysical Methods·J F Schmitt, M T Hearn
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·J B WelshG M Hampton
Jun 22, 2006·Journal of the National Cancer Institute·Paul W Finch, Jeffrey S Rubin
Oct 26, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T LushnikovaM Miettinen
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Vanessa Villegas-Ruiz, Sergio Juarez-Mendez

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