Aberrant forms of Escherichia coli in blood cultures: in vitro reproduction of an in vivo observation.

Journal of Clinical Microbiology
C R Magnussen, J F Hruska

Abstract

Aberrant filamentous forms of Escherichia coli were observed on direct Gram stain of blood cultures from a patient being treated with the beta-lactam antibiotic cephalexin. After the institution of an alternative antibiotic regimen which included a different cell wall-active agent, E. coli of normal morphology was detected in blood cultures for an additional 48 h. Filamentous forms of E. coli could be reproduced reliably in vitro by incubating the organism in Mueller-Hinton broth containing various concentrations of cephalexin. Both supra- and subinhibitory concentrations of cephalexin resulted in filament formation after 4 h of incubation, whereas 24 h of incubation yielded intact filaments at only a narrow range of subinhibitory concentrations of cephalexin. In vitro comparison of the ability of cephalexin, cephalothin, ampicillin, and gentamicin to cause filamentous forms of E. coli showed that cephalexin and cephalothin produced pure filament formation after 4 h of incubation at subinhibitory concentrations of as low as one-fourth the minimum inhibitory concentration of the antibiotic. Ampicillin was not associated with pure filament formation at concentrations below the minimum inhibitory concentration, and gentamicin prod...Continue Reading

References

Mar 1, 1975·The Journal of Clinical Investigation·J F AcarP A Ruch
Nov 1, 1975·American Journal of Clinical Pathology·V Lorian, B Atkinson
Sep 1, 1979·Reviews of Infectious Diseases·J A Washington
Aug 1, 1973·The Journal of Infectious Diseases·D Greenwood, F O'Grady

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Citations

Jan 1, 1982·Critical Reviews in Microbiology·B A Atkinson, L Amaral
Jul 17, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Shin-Ichi NakamuraYumi Une
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·T P Tim CushnieAndrew J Lamb
Aug 1, 1982·Journal of Clinical Microbiology·V LorianY Kim
Jul 17, 2012·Biomacromolecules·Toshiyuki YaguchiShuichi Takayama

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