Aberrant functional connectivity in depression as an index of state and trait rumination

Scientific Reports
David RosenbaumAnn-Christine Ehlis

Abstract

Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.

Associated Clinical Trials

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Citations

Oct 17, 2019·Frontiers in Behavioral Neuroscience·Moritz Julian MaierAnn-Christine Ehlis
Jun 28, 2018·Cognitive, Affective & Behavioral Neuroscience·Maureen D SatyshurJacqueline K Gollan
Sep 26, 2020·Scientific Reports·David RosenbaumAnn-Christine Ehlis
Oct 24, 2018·Scientific Reports·David RosenbaumFlorian G Metzger
Jan 30, 2019·Frontiers in Human Neuroscience·Florens GoldbeckAnn-Christine Ehlis
Dec 16, 2020·Brain and Behavior·Daniel BrennanLaurel S Morris
Feb 15, 2021·Reviews in the Neurosciences·Bernard J BorserioLinda L Agnew
Dec 21, 2021·Neuroscience and Biobehavioral Reviews·Leila ChaiebJuergen Fell

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Clinical Trials Mentioned

NCT02375308

Software Mentioned

MATLAB
matlab NBS toolbox
Wavelab850
BrainNetViewer

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