Aberrant Functional Connectivity in the Default Mode and Central Executive Networks in Subjects with Schizophrenia - A Whole-Brain Resting-State ICA Study

Frontiers in Psychiatry
Harri LittowVesa Kiviniemi

Abstract

Neurophysiological changes of schizophrenia are currently linked to disturbances in connectivity between functional brain networks. Functional magnetic resonance imaging studies on schizophrenia have focused on a few selected networks. Also previously, it has not been possible to discern whether the functional alterations in schizophrenia originate from spatial shifting or amplitude alterations of functional connectivity. In this study, we aim to discern the differences in schizophrenia patients with respect to spatial shifting vs. signal amplitude changes in functional connectivity in the whole-brain connectome. We used high model order-independent component analysis to study some 40 resting-state networks (RSN) covering the whole cortex. Group differences were analyzed with dual regression coupled with y-concat correction for multiple comparisons. We investigated the RSNs with and without variance normalization in order to discern spatial shifting from signal amplitude changes in 43 schizophrenia patients and matched controls from the Northern Finland 1966 Birth Cohort. Voxel-level correction for multiple comparisons revealed 18 RSNs with altered functional connectivity, 6 of which had both spatial and signal amplitude change...Continue Reading

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Citations

Mar 10, 2016·Frontiers in Psychiatry·Kathryn RiegerThomas Koenig
Feb 17, 2018·ELife·Janine Diane BijsterboschStephen M Smith
Oct 16, 2019·Autism Research : Official Journal of the International Society for Autism Research·Yu LiXiaoxiao Wang
Oct 27, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Qiyong GongAndrea Mechelli
Jul 2, 2020·Neuropsychiatric Disease and Treatment·Sung Woo JooJungsun Lee
Mar 5, 2016·Schizophrenia Bulletin·Leonhard SchilbachSimon B Eickhoff

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Software Mentioned

FSLs Randomize
concat
BET
MCFLIRT
rsfMRI
FSL
MELODIC

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