Aberrant functional connectome in neurologically asymptomatic patients with end-stage renal disease

PloS One
Xiaofen MaYikai Xu

Abstract

This study aimed to investigate the topological organization of intrinsic functional brain networks in patients with end-stage renal disease (ESRD). Resting-state functional MRI data were collected from 22 patients with ESRD (16 men, 18-61 years) and 29 age- and gender-matched healthy controls (HCs, 19 men, 32-61 years). Whole-brain functional networks were obtained by calculating the interregional correlation of low-frequency fluctuations in spontaneous brain activity among 1,024 parcels that cover the entire cerebrum. Weighted graph-based models were then employed to topologically characterize these networks at different global, modular and nodal levels. Compared to HCs, the patients exhibited significant disruption in parallel information processing over the whole networks (P < 0.05). The disruption was present in all the functional modules (default mode, executive control, sensorimotor and visual networks) although decreased functional connectivity was observed only within the default mode network. Regional analysis showed that the disease disproportionately weakened nodal efficiency of the default mode components and tended to preferentially affect central or hub-like regions. Intriguingly, the network abnormalities correl...Continue Reading

References

Dec 1, 1991·Stroke; a Journal of Cerebral Circulation·A PostiglioneS Federico
Oct 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D GottliebE Melamed
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Feb 1, 1994·Stroke; a Journal of Cerebral Circulation·R HataT Kamada
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
May 1, 1996·Kidney International·N H PliskinJ G Umans
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
Feb 19, 2002·Kidney International·Yasuo KuwabaraMasatoshi Fujishima
May 4, 2002·Science·Sergei Maslov, Kim Sneppen
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Aug 22, 2003·Nature·Daniel M Abrams, Steven H Strogatz
Mar 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mark A WilliamsPeter J Donovick
Aug 21, 2004·Neuroinformatics·Olaf Sporns, Jonathan D Zwi
Oct 28, 2004·Journal of the American Geriatrics Society·Manjula KurellaKristine Yaffe
Nov 9, 2004·British Journal of Anaesthesia·H SkinnerR Mahajan
Nov 30, 2004·Clinical Neurology and Neurosurgery·R Brouns, P P De Deyn
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M E J Newman
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Danielle Smith Bassett, Ed Bullmore
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Feb 13, 2007·Journal of Clinical Epidemiology·Kirsten Schultz-LarsenSvend Kreiner
Apr 5, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Isak ProhovnikErik Langhoff
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Robert N Foley, Allan J Collins
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anne M MurrayRobert N Foley
Feb 7, 2008·Seminars in Dialysis·Magdalena MaderoMark J Sarnak
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Apr 12, 2008·Cerebral Cortex·Michael D GreiciusRobert F Dougherty
Apr 30, 2008·International Urology and Nephrology·Sarbjit V JassalSean Rourke
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jul 12, 2008·Nature Physics·Roger GuimeràLuís A N Amaral
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns

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Citations

Jul 15, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shumei LiGuihua Jiang
Jun 13, 2015·BioMed Research International·Hui Juan ChenGuang Ming Lu
Apr 25, 2020·PeerJ·Mei JinZhenchang Wang
Mar 9, 2018·Frontiers in Psychiatry·Xiaofen MaTianyue Wang

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