Aberrant hemodynamic responses in autism: Implications for resting state fMRI functional connectivity studies

NeuroImage. Clinical
Wenjing YanGopikrishna Deshpande

Abstract

Functional MRI (fMRI) is modeled as a convolution of the hemodynamic response function (HRF) and an unmeasured latent neural signal. However, HRF itself is variable across brain regions and subjects. This variability is induced by both neural and non-neural factors. Aberrations in underlying neurochemical mechanisms, which control HRF shape, have been reported in autism spectrum disorders (ASD). Therefore, we hypothesized that this will lead to voxel-specific, yet systematic differences in HRF shape between ASD and healthy controls. As a corollary, we also hypothesized that such alterations will lead to differences in estimated functional connectivity in fMRI space compared to latent neural space. To test these hypotheses, we performed blind deconvolution of resting-state fMRI time series acquired from large number of ASD and control subjects obtained from the Autism Brain Imaging Data Exchange (ABIDE) database (N = 1102). Many brain regions previously implicated in autism showed systematic differences in HRF shape in ASD. Specifically, we found that precuneus had aberrations in all HRF parameters. Consequently, we obtained precuneus-seed-based functional connectivity differences between ASD and controls using fMRI as well as u...Continue Reading

Citations

Nov 7, 2019·Journal of Neuroscience Research·Brian D BermanJason R Tregellas
Oct 23, 2019·Autism Research : Official Journal of the International Society for Autism Research·Ville RaatikainenVesa Kiviniemi
Jul 10, 2019·Molecular Autism·Jace B KingJeffrey S Anderson
Nov 19, 2020·Autism Research : Official Journal of the International Society for Autism Research·Aija KotilaVille Raatikainen
Oct 30, 2021·Frontiers in Neuroscience·Ignacio CifreDante R Chialvo

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