Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer

Breast Cancer Research and Treatment
Eriko TokunagaYoshihiko Maehara

Abstract

Taxanes are among the most active agents and they are now known to be an indispensable component in chemotherapy for breast cancer. However, some patients are resistant to taxanes and the identification of the molecular characteristics that can predict the sensitivity to taxanes would be useful in selecting the most appropriate patients to receive taxane therapy. Taxanes are antimicrotubular agents that promote microtubular assembly and stabilize microtubules by preventing depolymerization. They interfere with normal mitotic transition and causes cell cycle arrest in the G2-M metaphase. CHFR (checkpoint with forkhead-associated and ring finger) is a recently identified gene, which functions as an important checkpoint protein early in G2-M transition. Its activation delays the cell cycle in prophase and promotes cell survival in response to the mitotic stress induced by either nocodazole or taxane. CHFR is frequently downregulated in human cancers, mostly owing to the hypermethylation of its promoter region. CHFR downregulation has been found in primary cancers or in the established tumor cells of various origins, such as the lung, colon, esophagus, and stomach. The aberrant hypermethylation of CHFR promoter appears to be a good...Continue Reading

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Citations

Oct 9, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Eriko TokunagaYoshihiko Maehara
Dec 14, 2011·Cellular and Molecular Life Sciences : CMLS·Sheru Sanbhnani, Foong May Yeong
Jul 18, 2008·Translational Oncology·Lisa M Privette, Elizabeth M Petty
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Masafumi TakeshitaKatsuo Sueishi
Nov 1, 2007·British Journal of Cancer·F E HenkenR D M Steenbergen

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