Abstract
Taxanes are among the most active agents and they are now known to be an indispensable component in chemotherapy for breast cancer. However, some patients are resistant to taxanes and the identification of the molecular characteristics that can predict the sensitivity to taxanes would be useful in selecting the most appropriate patients to receive taxane therapy. Taxanes are antimicrotubular agents that promote microtubular assembly and stabilize microtubules by preventing depolymerization. They interfere with normal mitotic transition and causes cell cycle arrest in the G2-M metaphase. CHFR (checkpoint with forkhead-associated and ring finger) is a recently identified gene, which functions as an important checkpoint protein early in G2-M transition. Its activation delays the cell cycle in prophase and promotes cell survival in response to the mitotic stress induced by either nocodazole or taxane. CHFR is frequently downregulated in human cancers, mostly owing to the hypermethylation of its promoter region. CHFR downregulation has been found in primary cancers or in the established tumor cells of various origins, such as the lung, colon, esophagus, and stomach. The aberrant hypermethylation of CHFR promoter appears to be a good...Continue Reading
References
Sep 1, 1989·The Japanese Journal of Surgery
Nov 1, 1994·Leukemia & Lymphoma·C TangK Bhalla
Nov 5, 1994·Lancet·K Gelmon
Feb 1, 1997·Leukemia·Y HuangK Bhalla
Jul 4, 1997·The Journal of Biological Chemistry·P GiannakakouM S Poruchynsky
Mar 4, 1998·Current Opinion in Cell Biology·M A Jordan, L Wilson
Apr 1, 1998·Nature·D P CahillB Vogelstein
Dec 9, 1998·Molecular Cell·D YuM C Hung
Jun 15, 1999·Genomics·D P CahillC Lengauer
Jul 15, 2000·Oncology·E TokunagaK Sugimachi
Aug 10, 2000·Nature·D M Scolnick, T D Halazonetis
Apr 12, 2002·Oncogene·Kotaro MizunoTakashi Takahashi
Oct 12, 2002·Carcinogenesis·Yasuyuki ShibataYoshitaka Fujii
Jan 23, 2003·Carcinogenesis·Paul G CornWafik S El-Deiry
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Minoru ToyotaTakashi Tokino
Dec 5, 2003·Oncogene·Jacques BertholonAlain Puisieux
Dec 25, 2003·Molecular Carcinogenesis·Ayse E Erson, Elizabeth M Petty
Apr 3, 2004·Cancer Research·Tamotsu SudoNaoto T Ueno
May 13, 2004·British Journal of Cancer·T HondaT Motoyama
May 27, 2004·The Oncologist·John CrownWei-Seong Ooi
Jun 3, 2004·The Lancet Oncology·A K NowakD Ghersi
Jun 18, 2004·Oncology Reports·Hio Chung KangJae-Gahb Park
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takao TakahashiIgnacio I Wistuba
Mar 12, 2005·Carcinogenesis·Johann C BrandesJames G Herman
Jun 7, 2005·Molecular Carcinogenesis·Hiu Wing CheungXianghong Wang
Citations
Oct 9, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Eriko TokunagaYoshihiko Maehara
Mar 13, 2008·PloS One·Tomokazu FukudaHitoshi Nakagama
Dec 17, 2008·Pharmacogenomics·Kim M SmitsManon van Engeland
May 27, 2009·World Journal of Gastroenterology : WJG·Eiji OkiYoshihiko Maehara
Dec 14, 2011·Cellular and Molecular Life Sciences : CMLS·Sheru Sanbhnani, Foong May Yeong
Jul 18, 2008·Translational Oncology·Lisa M Privette, Elizabeth M Petty
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Masafumi TakeshitaKatsuo Sueishi
Jun 29, 2011·The Journal of Pathology·Cathy B MoelansPaul J van Diest
Nov 1, 2007·British Journal of Cancer·F E HenkenR D M Steenbergen
Jun 29, 2007·Cancer Research·Lisa M PrivetteElizabeth M Petty