Abstract
A rare insulin-immunoreactive neuroendocrine tumor of the duodenum in a 54 year old male is reported. The incidentally identified tumor was located on the anterior free wall of the duodenal bulb and measured approximately 6 mm in diameter. Uncomplicated endoscopic resection of the tumor was carried out. The lesion exhibited classic histologic features of insulinoma of the beta-islet cell type with stromal amyloid deposition. In addition to positive reactivities of chromogranin A, neuron-specific enolase, synaptophysin, Leu 7 (CD57), cystatin C, CA15-3 and cytokeratin, the non-argyrophilic tumor cells were strongly immunoreactive for insulin and C-peptide. The stromal amyloid was clearly labeled for amylin. A few cells were stained for somatostatin, whereas other hormones were negative. Interestingly, a few isolated insulin-positive cells were identified in the non-neoplastic duodenal mucosa in the proximity of the tumor. Immunoelectron microscopy using paraffin sections disclosed insulin-immunoreactive secretory granules in the cytoplasm. The patient exhibited no signs or symptoms of hypoglycemia. Serum insulin levels were not measured prior to resection. No tumors were demonstrated in the pancreas. Magnetic resonance imaging r...Continue Reading
References
Sep 1, 1977·The American Journal of Surgical Pathology·R J ReedJ C Harkin
Oct 22, 1977·Histochemistry·L I Larsson
Apr 1, 1992·Acta Pathologica Japonica·Y AbeY Tsutsumi
May 1, 1986·The American Journal of Surgical Pathology·Y DayalH J Wolfe
Oct 1, 1989·The American Journal of Surgical Pathology·A P BurkeE B Helwig
Sep 1, 1985·Gynecologic Oncology·K MorganJ S Scott
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·B StammP Saremaslani
May 1, 1986·Gastroenterology·K MiyazakiH Ibayashi
Feb 1, 1987·World Journal of Surgery·Z PosalakyI P Posalaky
Feb 15, 1988·Cancer·S MorgelloD R Alonso
Jan 1, 1985·Peptides·S FalkmerA Zetterberg
Jul 10, 1971·British Medical Journal·A R AdamsonN G Rothnie
Feb 1, 1984·Journal of Clinical Pathology·D F GriffithsG T Williams
Dec 1, 1981·Cancer·J AlumetsS Tibblin
Sep 1, 1980·The Tohoku Journal of Experimental Medicine·K Yoshikawa, H Wakasa
Feb 1, 1994·Diabetes·T D O'BrienP C Butler
Citations
Sep 6, 2013·Endocrine Pathology·Stefano La RosaCarlo Capella
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·K Martin HoffmannRobert T Jensen
Sep 1, 1999·Pathology International·M Murakami, Y Tsutsumi
Apr 22, 2015·World Journal of Gastroenterology : WJG·Jie LiuYu-Hua Zhang
Dec 20, 2019·BMC Surgery·Mengqing SunYupei Zhao