Aberrant interhemispheric functional connectivity in first-episode, drug-naïve major depressive disorder

Brain Imaging and Behavior
Hong YangHaiyan Xie

Abstract

Many studies have indicated that depression is associated with impairment of the topological organization of the brain functional network, which may lead to disruption of mood and cognition in depressive patients. The abnormality of homotopic connectivity provides a basis for the clinical manifestations of depression, such as emotional and cognitive disorders. Several studies have investigated the abnormal imbalance of homotopic regions between the hemispheres in depressive patients. However, the reported findings are inconsistent. Additionally, the published studies have focused on only the grey matter when investigating functional connectivity abnormalities of the bilateral cerebral hemispheres in major depressive disorder (MDD). The aim of this study is to investigate functional connectivity abnormalities of the bilateral cerebral hemispheres in patients with first-episode, drug-naïve MDD using a voxel-mirrored homotopic connectivity (VMHC) method. Based on DSM-IV diagnostic criteria, 23 first-episode, drug-naïve MDD patients were recruited, together with 20 gender- and age-matched healthy normal controls. A Philips Achieva 3.0 T MRI scanner was used to acquire brain functional images at resting state as well as high-resolut...Continue Reading

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Citations

Jul 2, 2020·Neuropsychiatric Disease and Treatment·Shuhua RanHaitao Li
May 25, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jeanette HuiZafiris J Daskalakis

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