Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export

International Journal of Cancer. Journal International Du Cancer
Shoko SaitoKyosuke Nagata

Abstract

The SET-CAN fusion gene is the product of a chromosomal rearrangement found on 9q34 associated with an acute undifferentiated leukemia. SET-CAN encodes an almost complete SET protein fused to the C-terminal two-thirds of CAN. SET is also known as TAF-Ibeta, a histone chaperone and intracellular inhibitor of protein phosphatase 2A, whereas CAN is identical to Nup214, a nucleoporin protein. To obtain insight into the leukemogenic function of SET/TAF-Ibeta-CAN/Nup214, we have examined its subcellular localization. Immunofluorescence analyses showed that SET/TAF-Ibeta and CAN/Nup214 are found in the nucleus and the nuclear envelope, respectively, whereas the majority of SET/TAF-Ibeta-CAN/Nup214 is localized in the nucleus. SET/TAF-Ibeta-CAN/Nup214 interacted with hCRM1, one of the nuclear export factors, and caused aberrant intracellular localization of hCRM1. In cells expressing SET/TAF-Ibeta-CAN/Nup214, a protein containing a nuclear export signal accumulated in the nucleus. The export of this protein was partially restored by overexpression of hCRM1. These results suggest that aberrantly localized molecules associated with SET/TAF-Ibeta-CAN/Nup214 may be involved in oncogenesis.

References

Apr 1, 1973·Virology·F L Graham, A J van der Eb
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K NagataK Matsumoto
May 10, 1996·The Journal of Biological Chemistry·M LiZ Damuni
Jan 1, 1995·Journal of Cell Science. Supplement·N Panté, U Aebi
Jun 11, 1999·Biochemical and Biophysical Research Communications·S SaitoK Nagata
Aug 24, 1999·Molecular and Cellular Biology·P AskjaerM Fornerod
Oct 6, 2000·The Journal of Cell Biology·C M BrennanJ A Steitz
Apr 5, 2001·The Journal of Biological Chemistry·M ForguesX W Wang
Dec 14, 2001·The Journal of Biological Chemistry·Dianbo QuRobert Z Qi
Aug 28, 2002·The Journal of Cell Biology·Janet M CronshawMichael J Matunis
Oct 31, 2002·The Journal of Biological Chemistry·Núria CanelaOriol Bachs

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Citations

Mar 18, 2010·The Journal of Biological Chemistry·Akiko TakedaNabeel R Yaseen
Dec 25, 2012·The Journal of Biological Chemistry·Stephanie RoloffRalph H Kehlenbach
Apr 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·M CapelsonM W Hetzer
Sep 21, 2010·Haematologica·Paolo GorelloCristina Mecucci
Jan 1, 2011·Genetics Research International·Maria Micaela Molina-NavarroSusana Rodriguez-Navarro
Mar 25, 2014·Seminars in Cancer Biology·Akiko Takeda, Nabeel R Yaseen
Jul 7, 2009·Seminars in Cell & Developmental Biology·Songli Xu, Maureen A Powers
Sep 24, 2008·Biochemical and Biophysical Research Communications·Masamitsu N AsakaKyosuke Nagata
Jun 23, 2009·EMBO Reports·Maya Capelson, Martin W Hetzer
Feb 20, 2007·Proteomics·Jorge VeraMontserrat Jaumot
Oct 29, 2015·The FEBS Journal·Jaya SangodkarGoutham Narla
Mar 2, 2016·Molecular Biology and Evolution·Samina NaseebDaniela Delneri
Apr 20, 2016·Frontiers in Oncology·Elena ArriazuMaría D Odero
Sep 5, 2015·Epigenetics & Chromatin·Qian ZhangJennifer K Nyborg
Apr 9, 2014·Biochimica Et Biophysica Acta·Xiaohong Wang, Shulin Li
Apr 14, 2010·Molecular Cell·Alwin Köhler, Ed Hurt
Feb 3, 2015·Frontiers in Oncology·Joshua Oaks, Besim Ogretmen
Apr 3, 2012·Drug Discoveries & Therapeutics·H M AbkalloN Kobayashi
Aug 15, 2014·Oncology Letters·Min-Hang Zhou, Qing-Ming Yang
Mar 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ryan M De PalmaBesim Ogretmen
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karin NebralSabine Strehl
Jul 29, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Sadik CigdemMitsuru Okuwaki

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