PMID: 2104182Jan 1, 1990Paper

Aberrant lymphocyte migration patterns in systemic lupus erythematosus (MRL/l, MRL/n) mice are independent of the micro-environment

Autoimmunity
N ManoliosL Schrieber

Abstract

Mice with systemic lupus erythematosus (SLE) have unusual patterns of lymphocyte traffic characterised by diminished uptake of intravenously injected autoimmune cells into lymph nodes. This study examines the influence of the lymphocyte micro-environment on this aberrant migratory behaviour. To evaluate lymph node lymphocyte-endothelial interactions which can affect lymphocyte distribution without the in vivo influence of liver and spleen, the in vitro high endothelial venule (HEV) binding assay was used. Lymph node HEV binding of autoimmune MRL-lpr/lpr (MRL/l) and MRL(-)+/+ (MRL/n) lymphocytes was increased when compared with CBA/T6 lymphocytes and contrasted with diminished lymph node uptake noted in vivo. This was independent of the lymph node source (MRL/l, MRL/n, CBA/T6) onto which the lymphocytes were overlaid. To examine the influence of the microenvironment on in vivo traffic, 21Cr-labelled lymph node cells from normal CBA/T6 mice were injected into sex-matched MRL/l, MRL/n and CBA/T6 recipients. The distribution of cells was the same in each recipient strain suggesting that the micro-environment had little influence on the lymphocyte trafficking profiles of autoimmune mice. This study supports the view that aberrant ly...Continue Reading

References

Mar 1, 1986·Immunological Investigations·L K JungG A Fernandes
Jan 1, 1986·Rheumatology International·L SchrieberT J Santoro
Jan 1, 1985·Advances in Immunology·A N Theofilopoulos, F J Dixon
Mar 1, 1969·The Journal of Experimental Medicine·J J Woodruff, B M Gesner
Jul 1, 1982·Arthritis and Rheumatism·R B Zurier

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