Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis

Journal of Clinical Pathology
C MaesawaT Masuda

Abstract

Aberrant expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed in gallbladder carcinomas, whereas the non-tumorous gallbladder epithelium is maspin negative. We investigated maspin expression in non-tumorous gallbladder epithelium in patients with cholelithiasis. An immunohistochemical study of maspin expression was performed in 69 patients with cholelithiasis and 30 patients with gastric cancer without cholelithiasis. Immunoreactivity for maspin was observed in focal and patchy regions of the gallbladder epithelium. Positive immunoreactivity for maspin was significantly associated with the presence of intestinal metaplasia in patients with cholelithiasis (p<0.05). The high incidence of aberrant maspin expression in both intestinal metaplasia and carcinoma of the gallbladder supports the assumption that intestinal metaplasia of the gallbladder may predispose to gallbladder carcinoma.

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Citations

Jul 4, 2012·Cancer Metastasis Reviews·Thomas M BodenstineMary J C Hendrix
Jun 3, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jeong KimKyu Taek Lee
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhila Khalkhali-Ellis
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Oct 4, 2007·The Journal of Craniofacial Surgery·Giovanna IezziFrancesco Carinci
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Kavita BaghelRajeshwar Nath Srivastava

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