Aberrant methylation of FAT4 and SOX11 in peripheral blood leukocytes and their association with gastric cancer risk

Journal of Cancer
Hongxu SunYashuang Zhao

Abstract

Background: Aberrant DNA methylation, especially tumor suppressor gene hypermethylation, is a well-recognized biomarker of initial tumorogenesis stages. FAT4 and SOX11 are putative tumor suppressor genes and can be down-regulated by hypermethylation in various cancers tissues. However, in peripheral blood leukocytes, the association between these two genes methylation status, as well as the effects of gene-environment interactions, and gastric cancer (GC) risk remain unclear. Methods: A hospital-based case-control study including 375 cases and 394 controls was conducted. Peripheral blood leukocytes DNA methylation status were detected by methylation-sensitive high-resolution melting (MS-HRM) assay. Logistic regression was adopted to analyze the relationship of FAT4 and SOX11 methylation with GC susceptibility. Results: Positive methylation (Pm) and total positive methylation (Tpm) of FAT4 were significantly increased the risk of GC (OR = 2.204, 95% CI: 1.168-4.159, P = 0.015; OR = 1.583, 95% CI: 1.031-2.430, P = 0.036, respectively). Compared with controls, cases exhibited higher SOX11 Pm frequencies with OR of 2.530 (95% CI: 1.289-4.969, P = 0.007). Nonetheless, no statistically significant association between SOX11 Tpm and GC...Continue Reading

Citations

Mar 22, 2020·Molecular Genetics & Genomic Medicine·Chao WangJianbo Shu
Aug 23, 2019·Expert Review of Anticancer Therapy·Shunsuke NakamuraYasuhiro Kodera
Sep 18, 2020·Global Medical Genetics·Darja Kanduc, Yehuda Shoenfeld
Mar 5, 2021·International Journal of Biological Macromolecules·Asal Jalal AbadiMichael R Hamblin
Apr 3, 2019·Biochimie·Tianjiao ShanYi-Wen Huang

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Methods Mentioned

BETA
exome sequencing

Software Mentioned

Primer Premier
Gene Scanning
SPSS

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