Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study

Psychological Medicine
Lena PalaniyappanPeter F Liddle

Abstract

The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in patients with schizophrenia. More recently, aberrant myelination of frontal fasciculi, especially, cingulum has been proposed to underlie delayed corollary discharges that can affect sense of agency and contribute to delusions of control (Schneiderian delusions). Using the magnetization transfer phenomenon at an ultra-high field 7T MRI, we investigated the putative myelin content of cingulum bundle in patients with schizophrenia. Seventeen clinically stable patients with schizophrenia and 20 controls were recruited for this 7T MRI study. We used a region-of-interest method and extracted magnetization transfer ratio (MTR) from left and right dorsal cingulum bundles and estimated patients v. controls differences. We also related the cingulum MTR values to the severity of Schneiderian delusions. Patients had a significant reduction in the MTR, indicating reduced myelin content, in the cingulum bundle (right cingulum Hedges' g = 0.91; left cingulum g = 0.03). The reduced MTR of left cingulum was associated with higher severity of Schneiderian delusions (τ = -0.45, p = 0.026) but no such relationship was seen for the right cingulum MTR (...Continue Reading

References

Apr 1, 1987·Acta Psychiatrica Scandinavica·R Tandon, J F Greden
Aug 1, 1970·British Journal of Psychology·M Annett
Aug 1, 1982·Archives of General Psychiatry·J F LeckmanM M Weissman
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M HenkelmanM J Bronskill
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Jan 5, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Peter F LiddleAnthony J Warren
Aug 3, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Nicolas FranckNancy C Andreasen
Dec 5, 2002·Neurochemical Research·Patrick R HofJoseph D Buxbaum
May 14, 2003·Archives of General Psychiatry·Kenneth L DavisVahram Haroutunian
Sep 7, 2004·Annals of Neurology·Klaus SchmiererDavid H Miller
Mar 4, 2005·Brain : a Journal of Neurology·Rachel L C Mitchell, Tim J Crow
Apr 4, 2006·Neuroscience and Biobehavioral Reviews·Mark WalterfangChristos Pantelis
Feb 23, 2007·The International Journal of Neuropsychopharmacology·Natalya A UranovaDiana D Orlovskaya
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kristine RoyGabriel Corfas
Jul 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Klaus SchmiererDavid H Miller
Sep 1, 2007·NeuroImage·John Ashburner
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Phillip Zhe Sun, A Gregory Sorensen
Sep 9, 2008·Acta Neuropathologica·Andrea SchmittPeter Falkai
Jan 20, 2009·Journal of Community Health·Alessio VienoMassimo Mirandola
Aug 18, 2009·NeuroImage·O E MouginP A Gowland
Feb 20, 2010·Current Opinion in Neurology·Guido Stoll, Martin Bendszus
Mar 20, 2010·Brain : a Journal of Neurology·Aristotle N VoineskosMartha E Shenton
Sep 22, 2010·Schizophrenia Bulletin·Thomas J WhitfordMartha E Shenton
Oct 19, 2010·Progress in Neurobiology·Nagahide TakahashiJoseph D Buxbaum
May 3, 2011·PloS One·Muhammad Farid Abdul-RahmanKang Sim
May 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Irene M VavasourAlex L MacKay
Sep 20, 2011·Nature Genetics·UNKNOWN Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
Jul 10, 2012·Cerebral Cortex·Aristotle N VoineskosJames L Kennedy
Apr 6, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lena PalaniyappanPeter F Liddle
Aug 21, 2013·Schizophrenia Bulletin·Andrea GoudriaanMark H G Verheijen
Mar 4, 2014·PloS One·Laramie E DuncanBruce M Cohen
May 30, 2014·Schizophrenia Bulletin·Peter Kochunov, L Elliot Hong
Jun 21, 2014·Schizophrenia Research·Souhel Najjar, Daniel M Pearlman
Sep 2, 2014·Psychiatry Research·Jennifer FitzsimmonsMarek Kubicki

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