Aberrant neural signatures of decision-making: Pathological gamblers display cortico-striatal hypersensitivity to extreme gambles

NeuroImage
Sofie V GelskovHartwig R Siebner

Abstract

Pathological gambling is an addictive disorder characterized by an irresistible urge to gamble despite severe consequences. One of the hallmarks of pathological gambling is maladaptive and highly risky decision-making, which has been linked to dysregulation of reward-related brain regions such as the ventral striatum. However, previous studies have produced contradictory results regarding the implication of this network, revealing either hypo- or hypersensitivity to monetary gains and losses. One possible explanation is that the gambling brain might be misrepresenting the benefits and costs when weighting the potential outcomes, and not the gains and losses per se. To address this issue, we investigated whether pathological gambling is associated with abnormal brain activity during decisions that weight the utility of possible gains against possible losses. Pathological gamblers and healthy human subjects underwent functional magnetic resonance imaging while they accepted or rejected mixed gain/loss gambles with fifty-fifty chances of winning or losing. Contrary to healthy individuals, gamblers showed a U-shaped response profile reflecting hypersensitivity to the most appetitive and most aversive bets in an executive cortico-st...Continue Reading

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Citations

Nov 13, 2019·Addiction Biology·Alexander GenauckNina Romanczuk-Seiferth
Sep 15, 2018·Molecular Psychiatry·Luke ClarkMartin Zack
Aug 7, 2019·Translational Psychiatry·Yansong LiGuillaume Sescousse
Jun 6, 2020·Psychopharmacology·Anja KräplinMichael N Smolka
Dec 5, 2020·Neuroscience and Biobehavioral Reviews·Simona RaimoGabriella Santangelo
Apr 6, 2021·Frontiers in Psychology·Ibuki KoanShin Nakagawa
Jun 15, 2021·Journal of Gambling Studies·Retina RimalFrederick Sundram
Aug 28, 2021·International Journal of Environmental Research and Public Health·Joseph TealUgo Pace
Dec 5, 2020·Journal of Behavioral Addictions·Eve H Limbrick-OldfieldLuke Clark
Nov 13, 2021·NeuroImage. Clinical·Priyamvada ModakJoshua W Brown

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