Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis

Biology Open
Nelson S YeeRosemary K Yee

Abstract

Our previous studies in zebrafish development have led to identification of the novel roles of the transient receptor potential melastatin-subfamily member 7 (TRPM7) ion channels in human pancreatic cancer. However, the biological significance of TRPM7 channels in pancreatic neoplasms was mostly unexplored. In this study, we determined the expression levels of TRPM7 in pancreatic tissue microarrays and correlated these measurements in pancreatic adenocarcinoma with the clinicopathological features. We also investigated the role of TRPM7 channels in pancreatic cancer cell invasion using the Matrigel(TM)-coated transwell assay. In normal pancreas, TRPM7 is expressed at a discernable level in the ductal cells and centroacinar cells and at a relatively high level in the islet endocrine cells. In chronic pancreatitis, pre-malignant tissues, and malignant neoplasms, there is variable expression of TRPM7. In the majority of pancreatic adenocarcinoma specimens examined, TRPM7 is expressed at either moderate-level or high-level. Anti-TRPM7 immunoreactivity in pancreatic adenocarcinoma significantly correlates with the size and stages of tumors. In human pancreatic adenocarcinoma cells in which TRPM7 is highly expressed, short hairpin RN...Continue Reading

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Citations

Feb 5, 2016·Seminars in Immunopathology·George ShapovalovNatalia Prevarskaya
Dec 17, 2015·Pflügers Archiv : European journal of physiology·Sebastian SchäferVladimir Chubanov
May 6, 2015·Biochimica Et Biophysica Acta·Tarik SmaniJuan A Rosado
May 19, 2018·Pharmaceuticals·Benedikt FelsAlbrecht Schwab
Aug 23, 2020·Cancers·Jason I E Bruce, Andrew D James
Feb 8, 2018·Physiological Reviews·Natalia PrevarskayaYaroslav Shuba
Jul 6, 2019·Frontiers in Physiology·Jimena CanalesOscar Cerda
Oct 23, 2019·World Journal of Gastroenterology : WJG·Kyle J AndersonPatricia M Scott
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Thibaut LefebvreMathieu Gautier
Mar 19, 2020·International Journal of Molecular Sciences·Paulina StokłosaChristine Peinelt
Aug 1, 2020·Frontiers in Pharmacology·Sendoa Tajada, Carlos Villalobos
Feb 23, 2020·Archives of Toxicology·Alison VanlaeysMathieu Gautier
Mar 15, 2020·Animals : an Open Access Journal From MDPI·Sungin LeeWan Hee Kim
Jan 17, 2021·Nutrients·Julie AuwercxMathieu Gautier
Sep 8, 2019·Cell Calcium·Valentina Trapani, Federica I Wolf
Nov 13, 2020·Frontiers in Pharmacology·Julie SchnipperHalima Ouadid-Ahidouch
Nov 3, 2020·Frontiers in Pharmacology·Giorgia ChinigòDimitra Gkika
Apr 13, 2021·Frontiers in Pharmacology·Verena HofschröerAlbrecht Schwab
Feb 23, 2021·Veterinary and Comparative Oncology·Seulji LeeWan Hee Kim

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Methods Mentioned

BETA
PCR
flow cytometry
light microscopy

Software Mentioned

R
ImageJ
R R Core Team
Adobe® Photoshop®

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