PMID: 9538137Jun 6, 1998Paper

Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer

International Journal of Oncology
T NakaN Kaibara

Abstract

The p16 tumor suppressor gene is thought to play an important role in cell cycle regulation by encoding for protein products that can inhibit the progression from G1 to S phase in the cell cycle. Recently, the p16 gene has been found to be mutated or deleted in a variety of different types of primary human malignant tumors and human-derived malignant tumor cell lines. In this study, primary ductal pancreatic adenocarcinomas from 32 human patients were analyzed immunohistochemically for expression of p16 protein, with emphasis on the role of abberant p16 protein expression as a prognostic indicator. In addition, the same tumors were also assessed for p53 protein expression, AgNOR counts, and DNA ploidy. Nineteen out of the 32 cases (59%) showed positive immunoreactivity for p16 protein in their tumors and a significant association was found between lack of p16 protein expression, and both advancing clinical stage classification of disease, and poorer survival (p<0.05). The rate of positive immunoreactivity for p53 protein expression was 59%, however, no clear association was found between p53 protein expression, and either clinical stage of disease, or survival. These findings suggest that alteration of the p53 gene may be a rel...Continue Reading

Citations

Mar 29, 2014·Journal of Cancer Research and Clinical Oncology·You WangLing-Qing Hu
Apr 23, 2008·Cancer Metastasis Reviews·Alexios StrimpakosKostas N Syrigos
Jan 16, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nha LeUNKNOWN GEMS collaborating group of Pancreas 2000
Oct 5, 2010·Cancer·Shi-He LiuF Charles Brunicardi
Sep 9, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GarceaD P Berry
Jul 24, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Despoina GeorgiadouGeorge C Zografos
Aug 19, 2008·Journal of Psychosomatic Research·Richard S BourneElizabeth L Sampson
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew V BiankinSusan M Henshall

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