Aberrant Peripheral Immune Function in a Good Syndrome Patient

Journal of Immunology Research
Xian ChenFang Wang

Abstract

Good's syndrome (GS) is often accompanied by recurrent respiratory infections and chronic diarrhea. The main purpose was to evaluate the peripheral immune status of a GS patient after thymoma resection. Twenty healthy volunteers were recruited as healthy controls (HCs). Flow cytometry was applied to determine the proportions of circuiting CD4+ T cells, CD8+ T cells, γδT cells, and regulatory T (Treg) cells in our GS patient. We also examined the proliferation capability of ex vivo CD4+ T cells and detected the levels of cytokines interferon- (IFN-) γ and interleukin-17A secreted by ex vivo immune cells from this GS patient. Compared with healthy control subjects, this GS patient had fewer B cells, an inverted ratio of CD4+/CD8+ cells, and more Treg cells in his peripheral blood. Additionally, the patient's Vδ2 T cell levels were significantly decreased despite having a normal percentage of γδT cells. Ex vivo peripheral CD4+ T cells from the patient showed insufficient proliferation and division potential as well as excessive expression of PD-1. Moreover, IFN-γ was predominantly derived from CD8+ T cells in this GS patient, rather than from CD4+ T cells and γδT cells. This GS patient had impaired T and B cell immunological alter...Continue Reading

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Citations

Jan 9, 2021·Immunology Letters·Kissy Guevara-HoyerSilvia Sánchez-Ramón
Jun 12, 2021·Frontiers in Immunology·Yiyun Shi, Chen Wang

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Methods Mentioned

BETA
PMA
flow cytometry
X-ray

Software Mentioned

FlowJo
SPSS

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