Aberrant Prefrontal-Thalamic-Cerebellar Circuit in Schizophrenia and Depression: Evidence From a Possible Causal Connectivity

International Journal of Neural Systems
Yuchao JiangDezhong Yao

Abstract

Neuroimaging studies have suggested the presence of abnormalities in the prefrontal-thalamic-cerebellar circuit in schizophrenia (SCH) and depression (DEP). However, the common and distinct structural and causal connectivity abnormalities in this circuit between the two disorders are still unclear. In the current study, structural and resting-state functional magnetic resonance imaging (fMRI) data were acquired from 20 patients with SCH, 20 depressive patients and 20 healthy controls (HC). Voxel-based morphometry analysis was first used to assess gray matter volume (GMV). Granger causality analysis, seeded at regions with altered GMVs, was subsequently conducted. To discover the differences between the groups, ANCOVA and post hoc tests were performed. Then, the relationships between the structural changes, causal connectivity and clinical variables were investigated. Finally, a leave-one-out resampling method was implemented to test the consistency. Statistical analyses showed the GMV and causal connectivity changes in the prefrontal-thalamic-cerebellar circuit. Compared with HC, both SCH and DEP exhibited decreased GMV in middle frontal gyrus (MFG), and a lower GMV in MFG and medial prefrontal cortex (MPFC) in SCH than DEP. Co...Continue Reading

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Citations

Mar 4, 2020·European Radiology·Sisi JiangCheng Luo
Mar 8, 2020·Schizophrenia Bulletin·Debo DongDezhong Yao
Oct 6, 2020·BioMed Research International·Yutong YaoCheng Luo
Jan 30, 2020·Frontiers in Neuroscience·Xi ChenCheng Luo
Oct 9, 2020·The Cerebellum·Gustavo L FranklinHélio A G Teive
Dec 29, 2020·International Journal of Neural Systems·Fo HuTao Zhang
Dec 24, 2020·International Journal of Neural Systems·Yongjie ZhuFengyu Cong
Apr 27, 2021·Frontiers in Neuroinformatics·Elzbieta OlejarczykArunas Germanavicius
Jun 9, 2021·Psychological Medicine·Debo DongCheng Luo

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