PMID: 6401845Feb 3, 1983Paper

Aberrant rearrangement of the kappa light-chain locus involving the heavy-chain locus and chromosome 15 in a mouse plasmacytoma

Nature
B G VanNessF Ruddle

Abstract

The creation of a functional antibody gene requires the precise recombination of gene segments initially separated on the chromosome. Frequently errors occur in the process, resulting in the formation of a non-functional gene. The non-functional genes can be generated by incomplete rearrangements, frameshifts, or the use of pseudo V or J joining segments. It is likely that these aberrant rearrangements arise by the same mechanism as is used in generating functional genes, a process which we have suggested may involve unequal sister chromatid exchange. Aberrant rearrangements of immunoglobulin genes occur in normal lymphocytes and play a major part in allelic exclusion. However, it has recently been suggested that aberrant rearrangements involving immunoglobulin and non-immunoglobulin genes may be involved in tumorigenesis. This suggestion has been stimulated by the frequent occurrence of translocations involving chromosomes known to carry immunoglobulin genes in B-cell malignancies. The rearrangement of non-immunoglobulin DNA to the heavy-chain locus has recently been reported. Some aberrant rearrangements of the kappa locus appear to be due to rearrangements to sites that do not include the conventional sequence for V gene seg...Continue Reading

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L J HarrisK B Marcu
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R P PerryM Weigert
Jan 1, 1981·Cold Spring Harbor Symposia on Quantitative Biology·P LederB Norman
Jan 1, 1981·Cold Spring Harbor Symposia on Quantitative Biology·R P PerryM Weigert
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J HöchtlH G Zachau
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B G Van NessM Weigert

❮ Previous
Next ❯

Citations

Oct 28, 1986·Biochimica Et Biophysica Acta·M Zijlstra, C J Melief
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E L Mather, R P Perry
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P D FahrlanderG Klein
Jan 1, 1984·Cancer Investigation·M Potter, J F Mushinski
Nov 1, 1987·Molecular and Cellular Biology·M A Shapiro, M Weigert
May 27, 1983·Science·P D'Eustachio, F H Ruddle

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.