Aberrant Regulation of mRNA m⁶A Modification in Cancer Development.

International Journal of Molecular Sciences
Junyun LuoZhaoyong Li

Abstract

N⁶-methyladenosine (m⁶A) is the most prevalent internal modification of eukaryotic messenger RNAs (mRNAs). The m⁶A modification in RNA can be catalyzed by methyltransferases, or removed by demethylases, which are termed m⁶A writers and erasers, respectively. Selective recognition and binding by distinct m⁶A reader proteins lead mRNA to divergent destinies. m⁶A has been reported to influence almost every stage of mRNA metabolism and to regulate multiple biological processes. Accumulating evidence strongly supports the correlation between aberrant cellular m⁶A level and cancer. We summarize here that deregulation of m⁶A modification, resulting from aberrant expression or function of m⁶A writers, erasers, readers or some other protein factors, is associated with carcinogenesis and cancer progression. Understanding the regulation and functional mechanism of mRNA m⁶A modification in cancer development may help in developing novel and efficient strategies for the diagnosis, prognosis and treatment of human cancers.

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Citations

Jan 19, 2019·Genes·Sorina DinescuMarieta Costache
Dec 6, 2019·Molecular Cancer·Liuer HeGang Yin
Nov 12, 2020·Reproduction in Domestic Animals = Zuchthygiene·Dandan ZhongHui Li
Oct 24, 2020·Angewandte Chemie·Anna OvcharenkoAndrea Rentmeister
May 19, 2021·Biomarker Research·Xue Zheng, Yuping Gong
Oct 25, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shuangjiang WuSuttichai Krisanaprakornkit
Dec 14, 2021·Frontiers in Genetics·Hao SuHongjun Li

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Methods Mentioned

BETA
chemical modifications
immunoprecipitation
biopsy

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