Aberrant Spontaneous Brain Activity in Patients with Mild Cognitive Impairment and concomitant Lacunar Infarction: A Resting-State Functional MRI Study

Journal of Alzheimer's Disease : JAD
Ling NiBing Zhang

Abstract

Lacunar infarctions (LI) have been associated with a cognitive decline and an increased risk of dementia. Whether and how the pattern of spontaneous brain activity in patients with mild cognitive impairment (MCI) differs in subjects with and without concomitant LI remains unclear. To compare the pattern of spontaneous brain activity in MCI patients with versus those without LI using resting-state functional magnetic resonance imaging (rs-fMRI). Forty-eight MCI patients, including 22 with LI [MCI-LI] and 26 without LI [MCI-no LI], and 28 cognitive normal subjects underwent rs-fMRI post-processed using regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF) methods. Compared with cognitively normal subjects, the MCI-LI patients had decreased ReHo in the precuneus/cuneus (Pcu/CU) and insula; decreased ALFF in the Pcu/CU and frontal lobe; and increased ALFF and ReHo in the temporal lobe. While the MCI-no LI group had increased ReHo and ALFF in the bilateral hippocampus and parahippocampal gyrus, frontal lobe, and decreased ALFF and ReHo in the temporal lobe. Compared with the MCI-no LI patients, those with MCI-LI had decreased ALFF in the frontal lobe; decreased ReHo in the Pcu/CU and insula; and increased...Continue Reading

References

Jan 5, 1999·Brain : a Journal of Neurology·N R SeldenM M Mesulam
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·R BarbaT Del Ser
Apr 13, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J C SharmaC Butcher
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerMonique M B Breteler
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Mar 28, 2003·The New England Journal of Medicine·Sarah E VermeerMonique M B Breteler
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Christian BoctiSandra E Black
May 10, 2006·Archives of Neurology·Liana G ApostolovaPaul M Thompson
Feb 24, 2007·Journal of the Neurological Sciences·Marta Grau-OlivaresCarme Junqué
Aug 28, 2007·NeuroImage·Marcus E Raichle, Abraham Z Snyder
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong HeAlan Evans
Nov 22, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sang Won SeoDuk L Na
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerKeith A Johnson
Feb 18, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sang Won SeoDuk L Na
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Sep 10, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Ann I ScherLenore J Launer
May 27, 2011·Neuro-degenerative Diseases·Laura van de PolHenrike Wolf
Apr 6, 2012·Current Neurology and Neuroscience Reports·Huw R MorrisDerek J Blake
Aug 13, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Jamie Yu Jin ThongAnqi Qiu

❮ Previous
Next ❯

Citations

Nov 18, 2018·Translational Neurodegeneration·Dan ZhenPing Lei Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.