Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment.

Movement Disorders : Official Journal of the Movement Disorder Society
Pauline BelujonAnthony A Grace

Abstract

Chronic levodopa treatment for Parkinson's disease often results in the development of abnormal involuntary movement, known as L-dopa-induced dyskinesia (LIDs). Studies suggest that LIDs may be associated with aberrant corticostriatal plasticity. Using in vivo extracellular recordings from identified Type I and Type II medium spiny striatal neurons, chronic L-dopa treatment was found to produce abnormal corticostriatal information processing. Specifically, after chronic L-dopa treatment in dopamine-depleted rats, there was a transition from a cortically evoked long-term depression (LTD) to a complementary but opposing form of plasticity, long-term potentiation, in Type II "indirect" pathway neurons. In contrast, LTD could still be induced in Type I neurons. Interestingly, the one parameter that correlated best with dyskinesias was the inability to de-depress established LTD in Type I medium spiny striatal neurons. Taken as a whole, we propose that the induction of LIDs is due, at least in part, to an aberrant induction of plasticity within the Type II indirect pathway neurons combined with an inability to de-depress established plastic responses in Type I neurons. Such information is critical for understanding the cellular mech...Continue Reading

References

Nov 1, 1993·Journal of Neurophysiology·D M LovingerA Merritt
Nov 4, 1996·Brain Research·L D MercerG Paxinos
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Charpier, J M Deniau
Jan 1, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D CentonzeG Bernardi
Oct 29, 2000·Trends in Neurosciences·J A ObesoC W Olanow
Oct 29, 2000·Trends in Neurosciences·S P OnnA A Grace
Oct 29, 2000·Trends in Neurosciences·C R Gerfen
Oct 29, 2000·Trends in Neurosciences·T N Chase, J D Oh
May 16, 2001·Journal of Neurophysiology·J S FitzpatrickJ P Walsh
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hank P Jedema, Anthony A Grace
Apr 1, 2003·Nature Neuroscience·Barbara PicconiPaolo Calabresi
Jun 16, 2004·Parkinsonism & Related Disorders·Pierre J BlanchetPaul J Bédard
Jul 24, 2004·Trends in Neurosciences·Severine MahonStephane Charpier
Feb 19, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio PisaniPaolo Calabresi
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MalletFrançois Gonon
Sep 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pauline BelujonAbdelhamid Benazzouz

❮ Previous
Next ❯

Citations

Jun 6, 2012·Parkinson's Disease·Veronica GhiglieriPaolo Calabresi
Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yiyue ZhangKathy Steece-Collier
Jun 20, 2012·Basal Ganglia·Kathy Steece-CollierKatherine Soderstrom
Aug 20, 2011·Trends in Neurosciences·John LismanEmrah Duzel
Dec 15, 2010·Experimental Neurology·A SuppaA Berardelli
Feb 13, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Pauline Belujon, Anthony A Grace
May 30, 2012·Journal of Neurochemistry·Aisa N ChepkovaOlga A Sergeeva
Aug 7, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·James T TeoKailash Bhatia
Mar 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio SuppaAlfredo Berardelli
Nov 19, 2013·The European Journal of Neuroscience·Nicole A CrowleyYolanda Mateo
Jul 26, 2015·Progress in Neurobiology·Matthieu F BastideErwan Bézard
Mar 1, 2011·Journal of Neuroscience Methods·Sherri L ThieleJoanne E Nash
May 27, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paolo CalabresiBarbara Picconi
Jan 21, 2017·Translational Neurodegeneration·Jing Pan, Huaibin Cai
Mar 2, 2018·Journal of Neural Transmission·Barbara PicconiPaolo Calabresi
Apr 17, 2013·Nature Reviews. Neurology·Xiaoxi ZhuangUn Jung Kang
Sep 15, 2018·Behavioural Pharmacology·Adjia HamadjidaPhilippe Huot
Oct 18, 2019·Expert Opinion on Drug Safety·Valentina LetaAngelo Antonini
Aug 3, 2013·Reviews in the Neurosciences·Ulrike RichterPer Petersson
Jan 10, 2017·Frontiers in Neural Circuits·Qiang Wang, Wangming Zhang
Feb 6, 2018·ACS Chemical Neuroscience·Shana M Augustin, David M Lovinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.